A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis

Table 1 Tumor and treatment characteristics

	SF-SRS [n = 222 (%)]	HF-SRS [n = 113 (%)]	Unadjusted p-value	Adjusted p-value
Tumor location			0.64	0.82
Supratentorial	172 (78)	82 (73)
Infratentorial	50 (22)	31 (27)
Tumor size			< 0.001	0.01
≤ 2 cm	199 (90)	71 (63)
> 2 cm	23 (10)	42 (37)
Histology			0.07	0.07
Renal Cell	23 (10)	5 (4)
Melanoma	18 (8)	14 (12)
Squamous Cell	6 (3)	12 (11)
Adenocarcinoma^a	148 (67)	60 (53)
Other	27 (12)	22 (20)
Surgical resection			0.005	0.02
	8 (4)	18 (16)
Prior WBRT			0.61	0.30
	74 (33)	38 (34)
Concurrent systemic therapy			0.02	0.72
	73 (33)	18 (16)

WBRT whole brain radiation therapy
^aAdenocarcinoma includes adenocarcinoma of the lung and invasive ductal carcinoma of the breast

ISSN: 1748-717X