Table 2 Acute and late Treatment-related toxicity
Toxicity | Newly diagnosed group (n = 36) | Recurrent group (n = 18) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | |
Haematological | ||||||||||
Leukocytopenia | 7 (19.4) | 11 (30.6) | 4 (11.1) | 7 (19.4) | 0 | 4 (22.2) | 5 (27.8) | 3 (16.7) | 2 (11.1) | 0 |
Anaemia | 12 (33.3) | 8 (22.2) | 1 (2.8) | 0 | 0 | 8 (44.4) | 4 (22.2) | 1 (5.6) | 0 | 0 |
Thrombocytopenia | 7 (19.4) | 4 (11.1) | 0 | 0 | 0 | 1 (5.6) | 1 (5.6) | 1 (5.6) | 0 | 0 |
Hypokalemia | 1 (2.8) | 0 | 5 (13.9) | 0 | 0 | 1 (5.6)) | 0 | 1 (5.6) | 0 | 0 |
Hyponatremia | 3 (8.3) | 0 | 2 (5.6) | 0 | 0 | 1 (5.6) | 0 | 0 | 0 | 0 |
Non-Hematological | ||||||||||
Fever | 7 (19.4) | 2 (5.6) | 0 | 0 | 1 (2.8) | 3 (16.7) | 1 (5.6) | 0 | 0 | 0 |
Esophagitis | 21 (58.3) | 3 (8.3) | 4 (11.1) | 0 | 0 | 9 (50.0) | 1 (5.6) | 2 (11.1) | 0 | 1 (5.6) |
Tracheo-oesophageal fistula | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (5.6) |
Pneumonitis | 16 (44.4) | 6 (16.7) | 2 (5.6) | 0 | 1 (2.8) | 4 (22.2) | 4 (22.2) | 1 (5.6) | 0 | 0 |
Fatigue | 12 (33.3) | 7 (19.4) | 8 (22.2) | 0 | 0 | 4 (22.2) | 2 (11.1) | 3 (16.7) | 0 | 0 |
Nausea | 12 (33.3) | 3 (8.3) | 0 | 0 | 0 | 1 (5.6) | 2 (11.1) | 0 | 0 | 0 |
Vomiting | 5 (13.9) | 1 (2.8) | 0 | 0 | 0 | 1 (5.6) | 1 (5.6) | 0 | 0 | 0 |
Anorexia | 11 (30.6) | 4 (11.1) | 5 (13.9) | 0 | 0 | 4 (22.2) | 2 (11.1) | 2 (11.1) | 0 | 0 |
Diarrhea | 2 (5.6) | 1 (2.8) | 0 | 0 | 0 | 0 | 1 (5.6) | 0 | 0 | 0 |
Dermatitis | 6 (16.7) | 2 (7.4) | 1 (2.8) | 0 | 0 | 0 | 2 (11.1) | 3 (16.7) | 0 | 0 |
Hiccups | 1 (2.8) | 0 | 0 | 0 | 0 | 1 (5.6) | 0 | 0 | 0 | 0 |
Hoarseness | 5 (13.9) | 1 (2.8) | 0 | 0 | 0 | 3 (16.7) | 0 | 0 | 0 | 0 |
Arthralgia And Myalgia | 2 (5.6) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Weight Loss | 8 (22.2) | 3 (8.3) | 0 | 0 | 0 | 3 (16.7) | 1 (5.6) | 0 | 0 | 0 |
Pleural effusion | 6 (16.7) | 0 | 0 | 0 | 0 | 1 (5.6) | 0 | 0 | 0 | 0 |
Cardiac disorder | 10 (27.8) | 0 | 0 | 0 | 0 | 4 (22.2) | 0 | 0 | 0 | 0 |
Pulmonary fibrosis | 13 (36.1) | 0 | 0 | 0 | 0 | 2 (11.1) | 0 | 0 | 0 | 0 |
Esophageal stenosis | 2 (5.6) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |