Radiation Oncology

Table 4 Univariate and multivariate analysis on OS

From: Brain metastases treated with hypofractionated stereotactic radiotherapy: 8 years experience after Cyberknife installation

		Univariate analyses			Multvariate analyses
Variable	N	HR	IC95%	p	HR	IC95%	p
Age	N = 389			0.0891			0.4633
< 70 vs ≥ 70		1.402	[0.69–1.525]		1.473	[0.574–1.353]
Sex	N = 387			0.0024			0.0139
Female vs Male		1.578	[1.175–2.12]		1.578	[1.08–2.00]
KPS	N = 389			0.0094			0.0094
v < 70 vs ≥70		0.622	[0.435–0.89]		0.769	[0.522–1.133]
RPA	N = 389			0.0301			0.4
II-III vs I		1.756	[1.08–2.854]		0.799	[0.472; 1.35]
m RPA	N = 389	1.700		0.001	1.74	[1.12–2.69]	0.014
II-III vs I			[1.1–2.854]
GPA	N = 389			0.0342			0.1411
< 3 vs ≥3		0.642	[0.427–0.968]		0.712	[0.45–1.12]
DS-GPA	N = 345			0.3525
< 3 vs ≥3		0.842	[0.587–1.209]
Surgery	N = 389			0.00111			0.0028
Yes vs No		1.623	[1.117–2.357]		1.86	[1.24–2.79]
Symptoms	N = 322			0.696
No vs Yes		0.956	[0.697–1.312]
Single BM	N = 389			0.696
Yes vs No		1.074	[0.752–1533]
Radiosensitivity	N = 389			0.2592
Yes vs No		0.83	[0.601–1.147]
Control of primary tumor	N = 373			0.0036			0,0087
Yes vs No		0.645	[0.480–0.867]		0.671	[0.497–0.904]
Systemic treatment	N = 370			0.6987
Yes vs No		0.942	[0.694–1.277]
Group	N = 389			0.0092			0,0089
Surgery + HFSRT vs HFSRT		0.601	[0.419–0.884]		0.410	[0.419–0.884]

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