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Table 3 Multivariate Analysis of Dose-volume Variables Associated with Pericardial Effusion

From: Pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy for esophageal cancer

Parameters Pericardial effusion of any grade Pericardial effusion ≥ Grade 3
P value HR (95% CI) P value HR (95% CI)
Heart
 Mean (Gy) < 0.001 9.792 (2.930–32.724) NA NA
 V5 (%) 0.001 6.670 (2.172–20.481) NA NA
 V10 (%) 0.001 7.292 (2.370–22.439) NA NA
 V20 (%) < 0.001 10.681 (2.844–40.111) NA NA
 V30 (%) < 0.001 10.813 (2.897–40.360) NA NA
 V40 (%) < 0.001 7.191 (2.487–20.796) NA NA
 V50 (%) 0.002 4.977 (1.790–13.842) NA NA
 V60 (%) 0.363 1.407 (0.674–2.937) 0.055 5.495 (0.967–31.234)
Pericardium
 Mean (Gy) < 0.001 9.597 (2.850–32.310) NA NA
 V5 (%) 0.001 6.408 (2.194–18.713) NA NA
 V10 (%) 0.001 8.507 (2.271–31.863) NA NA
 V20 (%) < 0.001 10.324 (2.780–38.343) NA NA
 V30 (%) 0.001 8.269 (2.503–27.319) 0.010 32.309 (2.311–451.777)
 V40 (%) < 0.001 7.064 (2.430–20.540) 0.005 16.715 (2.307–121.093)
 V50 (%) 0.001 5.312 (1.977–14.274) NA NA
 V60 (%) 0.349 1.406 (0.689–2.868) 0.025 7.545 (1.293–44.011)
  1. Variables taken into account in multivariate analysis included gender, tumor location, use of alcohol, cardiovascular disease and one of dose-volume parameters
  2. Abbreviations: Gy gray, NA not applicable, Vx percentage of the heart or pericardium volume receiving more than x gray