|
Parameters
|
Pericardial effusion of any grade
|
Pericardial effusion ≥ Grade 3
|
|---|
|
P value
|
HR (95% CI)
|
P value
|
HR (95% CI)
|
|---|
|
Heart
|
|
Mean (Gy)
|
< 0.001
|
9.792 (2.930–32.724)
|
NA
|
NA
|
|
V5 (%)
|
0.001
|
6.670 (2.172–20.481)
|
NA
|
NA
|
|
V10 (%)
|
0.001
|
7.292 (2.370–22.439)
|
NA
|
NA
|
|
V20 (%)
|
< 0.001
|
10.681 (2.844–40.111)
|
NA
|
NA
|
|
V30 (%)
|
< 0.001
|
10.813 (2.897–40.360)
|
NA
|
NA
|
|
V40 (%)
|
< 0.001
|
7.191 (2.487–20.796)
|
NA
|
NA
|
|
V50 (%)
|
0.002
|
4.977 (1.790–13.842)
|
NA
|
NA
|
|
V60 (%)
|
0.363
|
1.407 (0.674–2.937)
|
0.055
|
5.495 (0.967–31.234)
|
|
Pericardium
|
|
Mean (Gy)
|
< 0.001
|
9.597 (2.850–32.310)
|
NA
|
NA
|
|
V5 (%)
|
0.001
|
6.408 (2.194–18.713)
|
NA
|
NA
|
|
V10 (%)
|
0.001
|
8.507 (2.271–31.863)
|
NA
|
NA
|
|
V20 (%)
|
< 0.001
|
10.324 (2.780–38.343)
|
NA
|
NA
|
|
V30 (%)
|
0.001
|
8.269 (2.503–27.319)
|
0.010
|
32.309 (2.311–451.777)
|
|
V40 (%)
|
< 0.001
|
7.064 (2.430–20.540)
|
0.005
|
16.715 (2.307–121.093)
|
|
V50 (%)
|
0.001
|
5.312 (1.977–14.274)
|
NA
|
NA
|
|
V60 (%)
|
0.349
|
1.406 (0.689–2.868)
|
0.025
|
7.545 (1.293–44.011)
|
- Variables taken into account in multivariate analysis included gender, tumor location, use of alcohol, cardiovascular disease and one of dose-volume parameters
- Abbreviations: Gy gray, NA not applicable, Vx percentage of the heart or pericardium volume receiving more than x gray
