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Table 2 Univariate Analysis of Dose-volume Variables Associated with Pericardial Effusion

From: Pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy for esophageal cancer

Parameters Pericardial effusion of any grade Pericardial effusion ≥ Grade 3
Cutoff P value HR (95% CI) Cutoff P value HR (95% CI)
Heart
 Maximal (Gy) 67.24 0.239 1.485 (0.769–2.870) 55.24 0.222 3.695 (0.453–30.128)
 Mean (Gy) 23.45 0.001 5.876 (2.068–16.697) 30.99 0.133 81.645 (0.260–25,636.991)
 V5 (%) 76.55 0.002 4.585 (1.776–11.835) 92.00 0.126 93.028 (0.281–30,852.401)
 V10 (%) 68.15 0.001 4.739 (1.837–12.224) 84.20 0.134 81.108 (0.258–25,461.652)
 V20 (%) 50.70 0.001 6.942 (2.118–22.753) 73.90 0.137 77.714 (0.251–24,062.690)
 V30 (%) 33.55 0.001 7.235 (2.204–23.749) 57.45 0.130 85.917 (0.268–27,518.745)
 V40 (%) 27.90 0.001 4.283 (1.864–9.841) 31.90 0.137 77.772 (0.251–24,088.957)
 V50 (%) 10.55 0.002 3.797 (1.653–8.723) 10.95 0.161 60.587 (0.195–18,812.141)
 V60 (%) 9.30 0.054 1.909 (0.988–3.690) 26.00 0.021 7.133 (1.343–37.891)
Pericardium
 Maximal (Gy) 55.14 0.198 1.673 (0.764–3.663) 53.97 0.406 27.314 (0.011–66,655.501)
 Mean (Gy) 20.33 0.001 5.623 (1.981–15.958) 30.18 0.131 85.491 (0.267–27,370.316)
 V5 (%) 84.50 0.001 3.758 (1.709–8.262) 89.15 0.128 89.096 (0.275–28,826.399)
 V10 (%) 48.50 0.003 6.135 (1.876–20.066) 82.65 0.116 119.578 (0.305–46,932.571)
 V20 (%) 42.55 0.001 6.997 (2.141–22.863) 71.55 0.120 109.854 (0.295–40,886.708)
 V30 (%) 33.35 0.001 5.569 (1.961–15.817) 65.80 0.008 17.537 (2.137–143.927)
 V40 (%) 28.90 < 0.001 4.120 (1.868–9.086) 55.35 < 0.001 19.316 (3.711–100.530)
 V50 (%) 21.45 < 0.001 4.262 (2.086–8.708) 16.10 0.151 66.216 (0.215–20,359.365)
 V60 (%) 11.10 0.066 1.838 (0.961–3.514) 24.70 0.011 9.324 (1.676–51.885)
  1. Abbreviations: Gy gray, Vx percentage of the heart or pericardium volume receiving more than x gray