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Table 4 Multivariate Cox analyses of treatment modalities for OS (n = 20300)

From: Neoadjuvant radiotherapy improves overall survival for T3/4N+M0 rectal cancer patients: a population-based study of 20300 patients

  Treatment Multivariate P value
HR (95% CI)
T3/4N0M0 (n = 7808) Surgery alone 1  
Neoadjuvant RT 0.591 (0.533~0.654) < 0.001
Adjuvant RT 0.660 (0.581~0.749) < 0.001
Surgery + chemo 0.598 (0.466~0.768) < 0.001
T1/2N+M0 (n = 2163) Surgery alone 1  
Neoadjuvant RT 0.467 (0.372~0.587) < 0.001
Adjuvant RT 0.378 (0.299~0.477) < 0.001
Surgery + chemo 0.463 (0.342~0.628) < 0.001
T3/4N+M0 (n = 10,329) Surgery alone 1  
Neoadjuvant RT 0.436 (0.396~0.478) < 0.001
Adjuvant RT 0.478 (0.431~0.531) < 0.001
Surgery + chemo 0.495 (0.431~0.568) < 0.001
  1. Multivariate Cox analyses are adjusted by age, sex, race, marital status, tumour grade, tumour size and N stage; HR Hazard ratio, RT radiotherapy