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Table 2 Patient characteristics stratified by treatment modality (n = 20300)

From: Neoadjuvant radiotherapy improves overall survival for T3/4N+M0 rectal cancer patients: a population-based study of 20300 patients

Characteristics Level Only surgery
(n = 2955)
Surgery + chemotherapy
(n = 1447)
Neoadjuvant RT
(n = 12,133)
Adjuvant RT
(n = 3765)
P value
Age, years Mean ± SD 70.94 ± 13.680 59.60 ± 12.824 58.56 ± 12.305 60.28 ± 12.037
Median (range) 73 (20~101) 59 (17~92) 58 (17~99) 60 (21~95)  
≤60 708 (24.0%) 764 (52.8%) 6880 (56.7%) 1931 (51.3%) < 0.001
> 60 2247 (76.0%) 683 (47.2%) 5253 (43.3%) 1834 (48.7%)  
Sex Male 1556 (52.7%) 793 (54.8%) 7547 (62.2%) 2201 (58.5%) < 0.001
Female 1399 (47.3%) 654 (45.2%) 4586 (37.8%) 1564 (41.5%)  
Race White 2387 (80.8%) 1161 (80.2%) 9827 (81.0%) 3028 (80.4%) 0.027
Black 233 (7.9%) 121 (8.4%) 992 (8.2%) 317 (8.4%)  
American Indian /Alaska Native 9 (0.3%) 8 (0.6%) 117 (1.0%) 32 (0.8%)  
Asian or Pacific Islander 326 (11.0%) 157 (10.9%) 1197 (9.9%) 388 (10.3%)  
Marital status Married 1408 (47.6%) 882 (61.0%) 7221 (59.5%) 2323 (61.7%) < 0.001
Unmarried 1401 (47.4%) 504 (34.8%) 4495 (37.0%) 1342 (35.6%)  
Unknown 146 (4.9%) 61 (4.2%) 417 (3.4%) 100 (2.7%)  
Tumour grade Low 2423 (82.0%) 1163 (80.4%) 9149 (75.4%) 2977 (79.1%) < 0.001
High 495 (16.8%) 250 (17.3%) 1537 (12.7%) 687 (18.2%)  
Unknown 37 (1.3%) 34 (2.3%) 1447 (11.9%) 101 (2.7%)  
Tumour size 0~3 cm 654 (22.1%) 442 (30.5%) 3657 (30.1%) 1103 (29.3%) < 0.001
3~5 cm 1260 (42.6%) 577 (39.9%) 4752 (39.2%) 1508 (40.1%)  
> 5 cm 1041 (35.2%) 428 (29.6%) 3724 (30.7%) 1154 (30.7%)  
AJCC Stage II 1598 (54.1%) 343 (23.7%) 4653 (38.3%) 1214 (32.2%) < 0.001
III 1357 (45.9%) 1104 (76.3%) 7480 (61.7%) 2551 (67.8%)  
AJCC T Stage T1 93 (3.1%) 102 (7.0%) 168 (1.4%) 191 (5.1%) < 0.001
T2 240 (8.1%) 203 (14.0%) 699 (5.8%) 467 (12.4%)  
T3 2395 (81.0%) 1006 (69.5%) 10,057 (82.9%) 2765 (73.4%)  
T4 227 (7.7%) 136 (9.4%) 1209 (10.0%) 342 (9.1%)  
AJCC N Stage N0 1598 (54.1%) 343 (23.7%) 4653 (38.3%) 1214 (32.2%) < 0.001
N1 889 (30.1%) 717 (49.6%) 5598 (46.1%) 1541 (40.9%)  
N2 468 (15.8%) 387 (26.7%) 1882 (15.5%) 1010 (26.8%)  
Chemotherapy Yes 0 (0.0%) 1447 (100.0%) 11,890 (98.0%) 3445 (91.5%) < 0.001
No/Unknown 2955 (100.0%) 0 (0.0%) 243 (2.0%) 320 (8.5%)  
  1. RT radiotherapy. Low: well differentiated and moderately differentiated; High: Poorly differentiated and undifferentiated