Table 5 Multivariate Cox regression analysis demonstrates associations between ALC nadirs and baseline variables and outcomes during RT
Characteristic | PFS | DMFS | LRFS | ||||||
|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |
RIL grade (nadir) | |||||||||
G3 V.S G0–2 | 0.637 | 0.434–0.936 | 0.022 | NI | – | – | 0.491 | 0.310–0.780 | 0.003 |
G4 V.S G0–2 | NI | – | – | 2.567 | 1.059–6.219 | 0.037 | NI | – | – |
G3–4V.S G0–2 | 0.676 | 0.484–0.945 | 0.022 | NI | – | – | 0.548 | 0.360–0.835 | 0.005 |
Sex | |||||||||
Female | 1 | 1 | NI | ||||||
Male | 1.556 | 1.070–2.263 | 0.021 | 2.005 | 1.097–4.080 | 0.025 | NI | – | – |
Stage | |||||||||
II | 1 | NI | NI | ||||||
III | 1.632 | 0.940–20,832 | 0.082 | NI | – | – | NI | – | – |
IVa | 2.04 | 1.115–3.731 | 0.007 | NI | – | – | NI | – | – |
Induction or concurrent chemotherapy | |||||||||
None | 1 | 1 | |||||||
Induction only | 0.422 | 0.254–0.701 | 0.001 | NI | – | – | 0.386 | 0.210–0.709 | 0.002 |
Concurrent only | 0.299 | 0.172–0.520 | < 0.001 | NI | – | – | 0.206 | 0.098–0.434 | < 0.001 |
Both | 0.294 | 0.191–0.453 | < 0.001 | NI | – | – | 0.265 | 0.159–0.443 | < 0.001 |