Characteristic | PFS | DMFS | LRFS | ||||||
---|---|---|---|---|---|---|---|---|---|
HR | 95%CI | P value | HR | 95%CI | P value | HR | 95%CI | P value | |
RIL grade (nadir) | |||||||||
G3 V.S G0–2 | 0.662 | 0.451–0.970 | 0.034 | 1.102 | 0.538–2.255 | 0.791 | 0.509 | 0.322–0.807 | 0.004 |
G4 V.S G0–2 | 0.998 | 0.559–1.781 | 0.993 | 2.507 | 1.038–6.053 | 0.041 | 0.474 | 0.195–1.153 | 0.1 |
G3–4 V.S G0–2 | 0.668 | 0.480–0.930 | 0.017 | 1.046 | 0.594–1.842 | 0.875 | 0.505 | 0.333–0.766 | 0.001 |
Sex | |||||||||
Female | 1 | 1 | 1 | ||||||
Male | 1.6 | 1.103–2.321 | 0.013 | 2.129 | 1.167–3.882 | 0.014 | 1.245 | 0.792–1.958 | 0.342 |
Age at diagnosis (years) | 0.996 | 0.980–1.013 | 0.649 | 1.003 | 0.980–1.028 | 0.78 | 0.991 | 0.970–1.012 | 0.388 |
Lymphocyte baseline | 0.992 | 0.740–1.331 | 0.958 | 0.928 | 0.585–1.472 | 0.751 | 1.039 | 0.710–1.521 | 0.844 |
Body mass index | 0.975 | 0.927–1.025 | 0.319 | 0.992 | 0.920–1.065 | 0.779 | 0.956 | 0.893–1.023 | 0.193 |
Smoking status (pack*year) | 1 | 1.000–1.001 | 0.039 | 1 | 1.000–1.001 | 0.128 | 1 | 1.000–1.001 | 0.192 |
Tumor histology (WHO) | |||||||||
Undifferentiated (III) | 1 | 1 | 1 | ||||||
Differentiated (I + II) | 1.402 | 1.003–1.960 | 0.048 | 1.445 | 0.880–2.371 | 0.146 | 1.285 | 0.836–1.973 | 0.253 |
Stage | |||||||||
II | 1 | 1 | 1 | ||||||
III | 1.335 | 0.786–2.266 | 0.285 | 1.811 | 0.715–4.587 | 0.21 | 1.257 | 0.662–2.385 | 0.485 |
IVa | 1.78 | 1.001–3.163 | 0.049 | 3.41 | 1.307–8.897 | 0.012 | 1.095 | 0.517–2.321 | 0.813 |
Prescribed dose (Gy) | 0.994 | 0.955–1.033 | 0.749 | 1 | 0.942–1.061 | 0.991 | 0.986 | 0.939–1.036 | 0.575 |
Induction or concurrent chemotherapy | |||||||||
None | 1 | 1 | |||||||
Induction only | 0.545 | 0.333–0.890 | 0.015 | 0.8 | 0.367–1.743 | 0.574 | 0.472 | 0.257–0.867 | 0.016 |
Concurrent only | 0.463 | 0.272–0.790 | 0.005 | 0.85 | 0.385–1.876 | 0.688 | 0.286 | 0.136–0.601 | 0.001 |
Both | 0.477 | 0.315–0.724 | < 0.001 | 0.673 | 0.338–1.339 | 0.259 | 0.388 | 0.232–0.649 | < 0.001 |
Adjuvant chemotherapy | |||||||||
No | 1 | 1 | 1 | ||||||
Yes | 0.959 | 0.687–1.338 | 0.806 | 1.341 | 0.837–2.150 | 0.223 | 0.69 | 0.435–1.094 | 0.115 |
Radiation modality | |||||||||
2D-CRT | 1 | 1 | 1 | ||||||
IMRT | 0.857 | 0.606–1.210 | 0.38 | 0.998 | 0.609–1.636 | 0.994 | 0.783 | 0.495–1.238 | 0.295 |