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Table 4 Univariate Cox regression analysis demonstrates associations between ALC nadirs and baseline variables and outcomes during RT

From: Radiation-induced lymphopenia correlates with survival in nasopharyngeal carcinoma: impact of treatment modality and the baseline lymphocyte count

Characteristic

PFS

DMFS

LRFS

HR

95%CI

P value

HR

95%CI

P value

HR

95%CI

P value

RIL grade (nadir)

 G3 V.S G0–2

0.662

0.451–0.970

0.034

1.102

0.538–2.255

0.791

0.509

0.322–0.807

0.004

 G4 V.S G0–2

0.998

0.559–1.781

0.993

2.507

1.038–6.053

0.041

0.474

0.195–1.153

0.1

 G3–4 V.S G0–2

0.668

0.480–0.930

0.017

1.046

0.594–1.842

0.875

0.505

0.333–0.766

0.001

Sex

 Female

1

  

1

  

1

  

 Male

1.6

1.103–2.321

0.013

2.129

1.167–3.882

0.014

1.245

0.792–1.958

0.342

Age at diagnosis (years)

0.996

0.980–1.013

0.649

1.003

0.980–1.028

0.78

0.991

0.970–1.012

0.388

Lymphocyte baseline

0.992

0.740–1.331

0.958

0.928

0.585–1.472

0.751

1.039

0.710–1.521

0.844

Body mass index

0.975

0.927–1.025

0.319

0.992

0.920–1.065

0.779

0.956

0.893–1.023

0.193

Smoking status (pack*year)

1

1.000–1.001

0.039

1

1.000–1.001

0.128

1

1.000–1.001

0.192

Tumor histology (WHO)

 Undifferentiated (III)

1

  

1

  

1

  

 Differentiated (I + II)

1.402

1.003–1.960

0.048

1.445

0.880–2.371

0.146

1.285

0.836–1.973

0.253

Stage

 II

1

  

1

  

1

  

 III

1.335

0.786–2.266

0.285

1.811

0.715–4.587

0.21

1.257

0.662–2.385

0.485

 IVa

1.78

1.001–3.163

0.049

3.41

1.307–8.897

0.012

1.095

0.517–2.321

0.813

Prescribed dose (Gy)

0.994

0.955–1.033

0.749

1

0.942–1.061

0.991

0.986

0.939–1.036

0.575

Induction or concurrent chemotherapy

 None

1

  

1

     

 Induction only

0.545

0.333–0.890

0.015

0.8

0.367–1.743

0.574

0.472

0.257–0.867

0.016

 Concurrent only

0.463

0.272–0.790

0.005

0.85

0.385–1.876

0.688

0.286

0.136–0.601

0.001

 Both

0.477

0.315–0.724

< 0.001

0.673

0.338–1.339

0.259

0.388

0.232–0.649

< 0.001

Adjuvant chemotherapy

 No

1

  

1

  

1

  

 Yes

0.959

0.687–1.338

0.806

1.341

0.837–2.150

0.223

0.69

0.435–1.094

0.115

Radiation modality

 2D-CRT

1

  

1

  

1

  

 IMRT

0.857

0.606–1.210

0.38

0.998

0.609–1.636

0.994

0.783

0.495–1.238

0.295

  1. Abbreviations: CI confidence interval, HR hazard ratio, 2D-CRT 2-dimensional conventional radiotherapy, IMRT intensity modulated radiation therapy, WHO World Health Organization