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Fig. 3 | Radiation Oncology

Fig. 3

From: Targeting human epidermal growth factor receptor 2 enhances radiosensitivity and reduces the metastatic potential of Lewis lung carcinoma cells

Fig. 3

Knockdown of HER2 (shHER2) inhibits HER2 activation, MMP-9 expression, and LLC cell invasiveness. a The expression of pHER2, HER2, and MMP-9 in wild-type (WT), vector control (shcontrol), and shHER2 LLC cells were evaluated after irradiation (RT, 7.5Gy, 16 h) by Western blotting. b WT, shcontrol, and shHER2 LLC cells were seeded in the Matrigel-coated inserts of Boyden chambers, and treated with RT (7.5Gy) or not. After 24 h, the invaded cells were viewed and counted microscopically (40X). * indicates p < 0.05. Comparisons were made between the wild-type and wild-type+RT group; shcontrol and shcontrol+RT group; and shHER2 and shHER2 + RT group

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