Variables | Univariable Analysis | Multivariable Analysis | ||
---|---|---|---|---|
HR (95.0% CI) | p-value | HR (95.0% CI) | p-value | |
Age at SBRT completiond | 0.996 (0.938–1.057) | 0.889 | ||
Gender | ||||
Male | Reference | |||
Female | 1.483 (0.389–5.662) | 0.564 | ||
ECOG performance status | ||||
0–1 | Reference | |||
2–3 | 1.157 (0.329–4.069) | 0.820 | ||
Age-adjusted Charlson comorbidity index d | 1.003 (0.726–1.387) | 0.983 | ||
COPD | ||||
No COPD | Reference | |||
GOLD stage 1–2 | 1.198 (0.318–4.510) | 0.789 | ||
GOLD stage 3–4 | 0.785 (0.140–4.409) | 0.783 | ||
Smoking status | ||||
Active smoker | Reference | |||
Past smoker | 0.688 (0.184–2.575) | 0.579 | ||
Never smoker | 0.598 (0.109–3.292) | 0.555 | ||
Tumor location | ||||
Central | Reference | |||
Ultracentral | 0.757 (0.217–2.642) | 0.663 | ||
Tumor type | ||||
Primary lung tumor | Reference | |||
Metastasis | 0.759 (0.163–3.536) | 0.726 | ||
ITV volume (cc) d | 1.049 (1.025–1.074) | < 0.001 | 1.047 (1.020–1.076) | 0.001 |
ITV Dmin a, d | 1.009 (0.974–1.046) | 0.607 | ||
ITV Dmax a, d | 1.059 (0.969–1.158) | 0.205 | ||
ITV Dmean a d | 1.025 (0.950–1.106) | 0.527 | ||
ITV V 60 Gy b, d | 1.037 (0.953–1.128) | 0.396 | ||
ITV D 99% a, d | 1.003 (0.965–1.043) | 0.876 | ||
ITV D 1% a, d | 1.044 (0.956–1.141) | 0.333 | ||
ITV volume receiving < 60 Gy (cc) d | 1.063 (0.894–1.264) | 0.488 | ||
PTV volume (cc) d, e | 1.029 (1.014–1.044) | < 0.001 | ||
PTV Dmin a, d | 1.003 (0.968–1.040) | 0.863 | ||
PTV Dmax a, d | 1.053 (0.961–1.154) | 0.266 | ||
PTV Dmean a, d | 1.037 (0.934–1.151) | 0.492 | ||
PTV V 60 Gy c, d | 1.010 (0.968–1.055) | 0.633 | ||
PTV D 99% a, d | 1.006 (0.960–1.054) | 0.795 | ||
PTV D 1% a, d | 1.042 (0.950–1.143) | 0.378 | ||
PTV volume receiving < 60 Gy (cc) d | 1.044 (1.008–1.081) | 0.017 | 1.006 (0.956–1.058) | 0.819 |