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Table 1 Baseline Patient and Tumor Characteristics

From: Outcomes of stereotactic body radiotherapy 60 Gy in 8 fractions when prioritizing organs at risk for central and ultracentral lung tumors

Characteristics

All Patients

n = 98

Central Tumors

n = 57

Ultracentral tumors

n = 41

p-value

Age at SBRT completion (years)

   

0.242

 Median

74.0

75.2

71.7

 

 Range

43.6–89.6

55.4–89.6

43.6–85.3

 

Gender

   

0.701

 Male

42 (42.9%)

23 (40.4%)

19 (46.3%)

 

 Female

56 (57.1%)

34 (59.6%)

22 (53.7%)

 

ECOG performance status

   

0.282

 0

16 (16.3%)

11 (19.3%)

5 (12.2%)

 

 1

55 (56.1%)

34 (59.6%)

21 (51.2%)

 

 2

24 (24.5%)

10 (17.5%)

14 (34.1%)

 

 3

3 (3.1%)

2 (3.5%)

1 (2.4%)

 

Smoking status

   

0.336

 Active smoker

27 (27.6%)

18 (31.6%)

9 (22.0)

 

 Past smoker

56 (57.1%)

29 (50.9%)

27 (65.9%)

 

 Never smoker

15 (15.3%)

10 (17.5%)

5 (12.2%)

 

COPD

   

0.249

 GOLD stage 1

15 (15.3%)

12 (21.1%)

3 (7.3)

 

 GOLD stage 2

29 (29.6%)

13 (22.8%)

16 (39.0%)

 

 GOLD stage 3

13 (13.3%)

8 (14.0%)

5 (12.2%)

 

 GOLD stage 4

2 (2.0%)

1 (1.8%)

1 (2.4%)

 

 GOLD stage unknown

2 (2.0%)

2 (3.5%)

0 (0%)

 

 No COPD

37 (37.8%)

21 (36.8%)

16 (39.0%)

 

Age-adjusted Charlson comorbidity index

   

0.942

 Median

7

7

7

 

 Range

4–11

4–11

4–11

 

Histology

   

0.378

 Primary lung tumors

76 (77.6%)

46 (80.7%)

30 (73.2%)

 

 Metastases

22 (22.4%)

11 (19.7%)

11 (26.8%)

 

T stage for primary lung tumors

   

0.304

 T1a

2 (2.0%)

2 (3.5%)

0 (0%)

 

 T1b

25 (25.5%)

16 (28.1%)

9 (22.0%)

 

 T1c

25 (25.5%)

17 (29.8%)

8 (19.5%)

 

 T2a

17 (17.3%)

7 (12.3%)

10 (24.4%)

 

 T2b

4 (4.1%)

2 (3.5%)

2 (4.9%)

 

 T3

2 (2.0%)

2 (3.5%)

0 (0%)

 

 T4

1 (1.0%)

0 (0%)

1 (2.4%)

 

Criteria to define central lung tumors

  

n/a

n/a

 1 – GTV within 2 cm of proximal bronchial tree

24 (24.5%)

24 (42.1%)

  

 2 – PTV overlaps mediastinal / pericardial pleura

31 (31.6%)

31 (54.4%)

  

 1 and 2

2 (2.0%)

2 (3.5%)

  

Criteria to define ultracentral lung tumors

 

n/a

 

n/a

 1 – PTV overlaps proximal bronchial tree

26 (26.5%)

 

26 (63.4%)

 

 2 – PTV overlaps esophagus

1 (1.0%)

 

1 (2.4%)

 

 3 – PTV overlaps pulmonary artery

2 (2.0%)

 

2 (4.9%)

 

 4 – PTV overlaps pulmonary vein

2 (2.0%)

 

2 (4.9%)

 

 1 and 3

8 (8.2%)

 

8 (19.5%)

 

 1 and 4

1 (1.0%)

 

1 (2.4%)

 

 2 and 4

1 (1.0%)

 

1 (2.4%)

 
  1. Abbreviations: SBRT stereotactic body radiotherapy, ECOG eastern cooperative oncology group, COPD chronic obstructive pulmonary disease, GOLD global initiative for chronic obstructive lung disease, GTV gross tumor volume, PTV planning target volume