Table 1 Clinical characteristics in patients with NPC treated with IMRT
Variable | Patients | Statistic | P-value | |
|---|---|---|---|---|
With HT (N = 104) | Without HT (N = 102) | |||
Age (mean ± SD) | 50.62 ± 10.75 | 52.21 ± 10.67 | t = 1.070 | 0.289 |
Sex | χ2 = 0.017 | 0.017* | ||
Male | 60 (29.13) | 75 (36.41) | ||
Female | 44 (21.36) | 27 (13.11) | ||
T stage (2010UICC) | χ2 = 0.004 | 0.947 | ||
T1–2 | 19 (9.22) | 19 (9.22) | ||
T3–4 | 85 (41.26) | 83 (40.29) | ||
N stage (2010UICC) | χ2 = 5.531 | 0.021* | ||
N0–1 | 27 (13.11) | 42 (20.39) | ||
N2–3 | 77 (37.38) | 60 (29.13) | ||
M stage (2010UICC) | 0.498a | |||
M0 | 98 (47.57) | 99 (48.06) | ||
M1 | 6 (2.91) | 3 (1.46) | ||
Clinical stage (2010UICC) | χ2 = 2.158 | 0.142 | ||
I-II | 4 (1.94) | 9 (4.37) | ||
III-IV | 100 (48.54) | 93 (45.15) | ||
Nimotuzumab | χ2 = 0.004 | 0.947 | ||
No | 85 (41.26) | 83 (40.29) | ||
Yes | 19 (9.22) | 19 (9.22) | ||
Neoadjuvant chemotherapy | χ2 = 1.500 | 0.221 | ||
No | 4 (1.94) | 8 (3.88) | ||
Yes | 100 (48.54) | 94 (45.63) | ||
Thyroid volume (cm3) | 12.77 (10.79–16.13) | 15.88 (13.33–19.97) | Z = 4.091 | < 0.001*** |
Mean dose of thyroid (Gy) | 46.08 (44.68–47.98) | 45.67 (42.86–47.05) | Z = -1.981 | 0.048* |
V20 | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | Z = -2.182 | 0.029* |
V25 | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | Z = -0.798 | 0.425 |
V30 | 1.00 (0.97–1.00) | 0.99 (0.95–1.00) | Z = -1.697 | 0.090 |
V35 | 0.93 (0.87–0.98) | 0.92 (0.78–0.96) | Z = -1.797 | 0.072 |
V40 | 0.77 (0.69–0.85) | 0.76 (0.59–0.82) | Z = -1.808 | 0.071 |
V45 | 0.56 (0.49–0.64) | 0.54 (0.40–0.60) | Z = -1.950 | 0.051 |
V50 | 0.33 (0.28–0.41) | 0.32 (0.23–0.38) | Z = -2.090 | 0.037* |
V55 | 0.11 (0.05–0.18) | 0.08 (0.05–0.15) | Z = -1.344 | 0.179 |
V60 | 0.01 (0.00–0.04) | 0.00 (0.00–0.02) | Z = -1.322 | 0.186 |
Pituitary volume (cm3) | 0.47 (0.36–0.55) | 0.43 (0.35–0.53) | Z = -1.259 | 0.208 |
Mean dose of pituitary (Gy) | 51.04 (43.26–57.09) | 52.78 (40.70–59.24) | Z = 0.770 | 0.441 |
V20 | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | Z = 0.439 | 0.661 |
V25 | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | Z = -0.633 | 0.527 |
V30 | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | Z = -0.420 | 0.674 |
V35 | 1.00 (0.88–1.00) | 1.00 (0.73–1.00) | Z = -0.892 | 0.372 |
V40 | 1.00 (0.62–1.00) | 1.00 (0.5–1.00) | Z = -0.801 | 0.423 |
V45 | 0.98 (0.41–1.00) | 1.00 (0.43–1.00) | Z = 0.501 | 0.616 |
V50 | 0.52 (0.00–1.00) | 0.81 (0.00–1.00) | Z = 0.867 | 0.386 |
V55 | 0.10 (0.00–0.56) | 0.39 (0.00–0.9) | Z = 1.247 | 0.213 |
V60 | 0.00 (0.00–0.46) | 0.00 (0.00–0.53) | Z = 0.823 | 0.411 |