Table 6 univariate and multivariate analysis of progression free survival (PFS)
PFS | P-value | |||
|---|---|---|---|---|
at 12 months (%) | at 24 months (%) | univariate Analysis | multivariate Analysis | |
Age | ||||
≤ 65 years | 50 | 19 | ||
> 65 years | 67 | 20 | 0.925 | |
Gender | ||||
Female | 80 | 20 | ||
Male | 54 | 19 | 0.868 | |
Karnofsky performance status | ||||
> 80% | 65 | 25 | ||
≤ 80% | 46 | 9 | 0.134 | |
UICC stage | ||||
III | 54 | 18 | ||
IV | 100 | 33 | 0.458 | |
T category | ||||
1–2 | 67 | 0 | ||
3–4 | 56 | 20 | 0.292 | |
N category | ||||
0–1 | 33 | 0 | ||
2–3 | 61 | 20 | 0.235 | |
Histology | ||||
Squamous cell carcinoma | 56 | 19 | ||
Non- Squamous cell carcinoma | 60 | 20 | 0.855 | |
Tobacco consumption (PY) | ||||
0 | 63 | 25 | ||
20–40 | 38 | 13 | ||
> 40 | 67 | 20 | 0.633 | |
Grading | ||||
Moderately differentiated | 50 | 50 | ||
Poorly differentiated | 59 | 15 | ||
anaplastic | 50 | 50 | 0.831 | |
PD-L1 expression | ||||
0% | 86 | 29 | ||
≥ 1% | 31 | 13 | 0.006 | 0.061 |
CD8+ TILs density | ||||
≤ 40% | 70 | 30 | ||
> 40% | 50 | 17 | 0.201 | |
TIME type | ||||
I | 100 | 60 | ||
II | 30 | 20 | ||
III | 71 | 14 | ||
IV | 40 | 0 | 0.035 | 0.144 |