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Table 1 Patient and treatment characteristics for all patients (left panel), ARO-analogue subgroup (middle panel) and HPVOPC (right panel)

From: Definitive chemoradiotherapy in patients with squamous cell cancers of the head and neck - results from an unselected cohort of the clinical cooperation group “Personalized Radiotherapy in Head and Neck Cancer”

FactorsAll patients ARO-analogue HPVOPC 
n = 184 n = 92 n = 25 
NumberPercentNumberPercentNumberPercent
Age
 < 4542.233.314.0
 45–543016.32325.014.0
 55–646635.73740.2832.0
 65–745328.82325.0936.0
 75–842714.766.5624.0
 > 8542.200.000.0
Sex
 male14377.77177.22080.0
 female4122.32122.8520.0
Diagnosis class
 first diagnosis16187.58389.22288.0
 disease recurrence2312.599.8312.0
Localization
 Oropharynx7842.44043.525100.0
 Larynx3720.11718.500.0
 Hypopharynx35192021.700.0
 Oral cavity3418.51516.300.0
Primary Tumor (T)
 cT1–23720.11314.1312.0
 cT3–414779.97985.92288.0
Lymph Nodes (N)
 cN0-cN2a7239.13538.0832.0
 cN2b-cN2c10557.15357.61768.0
 cN373.844.300.0
Metastasis (M)
 cM0184100.092100.025100.0
 cM100.000.000.0
Stage 7th edition (8th edition HPVOPC a)
 UICC I10.511.10 (2a)0.0 (8.0 a)
 UICC II84.355.41 (10 a)4.0 (40.0 a)
 UICC III3016.31516.34 (13 a)16.0 (52.0 a)
 UICC IV14578.87177.220 (0 a)80.0 (0.0 a)
Grading
 G173.833.300
 G28948.84346.7936.0
 G38345.84548.91664.0
 Gx52.711.100
p16 staining
 Positive3519.02122.825100.0
 Negative12165.85964.100.0
 unknown2815.21213.000.0
smoking history
 < 10 pack-years105.433.328.0
 > 10 pack-years9953.84953.3728.0
 unknown7540.84043.51664.0
Therapeutic Dose
 Median70 Gy 70 Gy 70 Gy 
 > = 66 Gy17997.39097.825100.0
 < 66 Gy52.722.200.0
GTV volume
 available17494.68794.62496.0
 missing105.455.414.0
 range (in cc)2–789 2–789 18–359 
 mean (in cc)61 106 107 
Chemotherapy
 no189.800.014.0
 yes16690.292100.02496.0
 MMC / 5FU925092100.01872.0
 MMC mono2815.200.028.0
 Platin based2614.100.014.0
 Cetuximab mono2010.900.0312.0
 Chemo completed13581.38491.32083.3
 Chemo stopped3118.788.7416.7
  patient refused1 1 0 
  worsening condition15 5 4 
  cytopenia9 1 0 
  reaction to chemo6 1 0 
Causes of death
 tumor related50 27 1 
 comorbidities40 21 6 
 therapy-associated0 0 0 
 second primary11 5 0 
 unknown12 5 1 
  1. aThe UICC 8th edition stage is shown in parenthesis (HPVOPC only)