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Table 1 Patient Characteristics (n = 37)

From: Clinical outcomes of previously untreated patients with unresectable intrahepatic cholangiocarcinoma following proton beam therapy

  

Curative group(n = 25)

Palliative group(n = 12)

Median Age (range)

68.4 (32–87)

72 (44–82)

67 (32–87)

Gender

 Male

22

17

5

 Female

15

8

7

Performance status

 0

12

11

1

 1

19

13

6

 2

6

1

5

 3

0

0

0

Child-Pugh Classification

 A

27

20

7

 B

27

5

5

Jaundice

 yes

26

21

5

 no

11

4

7

Treatment intent

 Curative

25

  

 Palliative

12

  

Median size of the tumor (range) (mm)

57 (15–140)

44 (15–140)

60 (22–110)

Number of tumor

 single

27

22

5

 multiple

10

3

7

TNM stage (7th UICC)

 I

4

4

0

 II

4

3

1

 III

0

0

0

 IVa

19

15

4

 IVb

10

3

7

T stage

 1

5

5

0

 2a

6

4

2

 2b

5

1

4

 3

1

1

0

 4

20

14

6

N stage

 0

21

17

4

 1

16

8

8

M stage

 0

27

22

5

 1

10

3

7

macroscopic subtype

 Mass forming (MF) type

19

13

6

 Intraductal growth (IG) type

7

4

3

 Periductal infiltrating (PI) type

11

8

3

Total dose

 66.0 GyE in 10 Fraction (BED*:109.6 Gy)

1

1

0

 72.6 GyE in 22 Fraction (BED:96.6 Gy)

21

19

2

 74.0 GyE in 37 Fraction (BED:88.8 Gy)

5

2

3

 Other (BED < 88.8Gy)

10

3

7

Concurrent chemotherapy

 TS-1

15

11

4

 Gemcitabine

1

1

0

 None

21

13

8

Adjuvant Chemotherapy

 TS-1

10

7

3

 Cisplatine + Gemcitabine

5

4

1

 Gemcitabine

4

2

2

 None

18

11

7

  1. *BED: biological effective dose (α/β = 10)