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Table 4 Relationship between tumor burden and outcome in the literature

From: Tumor burden and location as prognostic factors in patients treated by iodine seed implant brachytherapy for localized prostate cancers

 

Period of recruitment

Number of patients

Median number of biopsy cores

Median follow-up

Outcome

Grann et al., 1998 [16]

1988–1994

103

NA

3 years

5-year bPFS =

LT < 10 mm: 74%

LT > 10 mm: 36%

(p = 0.011, univariate / p = 0.15 multivariate)

Merrick et al., 2002 [57]

1995–1999

262 (111 with exclusive brachytherapy)

6 (2–15)

38.6 months

5-year bPFS = 92.5%

PPB < 34%: 96.6%

PPB 34–50%: 92.9%

PPB > 50%: 84.8%

(p = 0.017)

PPB not associated with bPFS within each risk group.

Merrick et al., 2004 [58]

1995–2001

413 (197 with exclusive brachytherapy)

NA

52 months

7-year bPFS =

PPB < 34%: 99.4%

PPB 34–50%: 94.3%

PPB > 50%: 89.2%

(p = 0.002)

Rossi et al., 2006 [17]

1997–1999

108

12

61 months

5-year bPFS = 87%

PPB < 50%: 95%

PPB > 50%: 63%

(p < 0.0001)

Guzzo et al., 2008 [18]

1992–2002

245

6.8 (1–18)

52.8 months

5-year bPFS: 82%

PPB < 27%: 89.1%

PPB > 27%: 73.8%

(p = 0.011)

Merrick et al., 2008 [59]

1995–2004

145

 

5.8 years

9-year bPFS = 97.1%

PPB = predictor of bPFS in multivariate analysis.

Potters et al., 2008 [19]

1992–2000

1449

NA

82 months

12-year bPFS = 78%

PPB independently associated with bPFS in the multivariate analysis (p = 0.037).

Taira et al., 2011 [20]

1995–2006

1656 (831 with exclusive brachytherapy)

NA

7 years

12-year bPFS = 95.6%

PPB > 34%: 98%

PPB 34–50%: 93%

PPB > 50%: 91.5%

(p < 0.001)

Hill et al., 2015 [60]

1998–2012

846

12

5.59 years

Biochemical failures: 62 (7.3%)

Failures: PPB = 32.8%

Non failures: PPB = 34.9%

NS

Martell et al., 2017 [61]

2003–2013

2608

NA

4,7 years

Estimated 7-year-bPFS = 93%

PPB not associated with bPFS.

Present study

2006–2013

282

12 (5–32)

61 months

Biochemical failures: 20 (7.1%)

Failures: PPB =17%

Non failures: PPB = 17%

NS

  1. Abbreviations: bPFS biochemical Progression Free Survival, PPB Percentage of Positive Biopsies, LT length of tumor, NS Non significant