Fig. 3

(a) The deposited energy distribution is calculated for both cohorts. (b) The range of isodose volumes within the particular isodoses in the rectal cancer cohort. (c) Correlation of the individual BMI value with the deposited energy for rectal and (d) lung cancer patients. (e) Chromosomal breakage rates after ex vivo IR using different IR doses. Linear dose-response curve (solid line) and the calculated linear-quadratic adjustment line (dashed line). The linear quadratic function was used to correct the formed chromosomal aberrations in dependence of the respectively dose volume. Distribution of the estimated average dose. The estimated average dose is the deposited energy of the different isodose volumes and is corrected for the chromosomal aberrations efficiency. (f) Additionally it is multiplied by the number of fractions and divided by the body weight of each patient