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Table 2 Determined values for TD50, BED50, RBE, RBEmax and α/β together with the single standard errors (SE) and 90%-confidence limits (CL)

From: Fractionated carbon ion irradiations of the rat spinal cord: comparison of the relative biological effectiveness with predictions of the local effect model

Study

TD50 ± SE (90% CL) [Gy]

RBE ± SE (90% CL)

(A) 6 Fx

 Photonsa

57.0 ± 2.0 (−)b

 

 Carbon ions

  16 keV/μm

39.1 ± 0.4 (38.2–40.0)

1.46 ± 0.05 (1.37–1.55)

  21 keV/μm

33.8 ± 0.6 (32.5–35.0)

1.69 ± 0.07 (1.58–1.80)

  36 keV/μm

28.7 ± 1.5 (−)b

1.98 ± 0.12 (1.79–2.21)

  45 keV/μm

26.9 ± 0.5 (25.7–28.1)

2.12 ± 0.08 (1.98–2.26)

  66 keV/μm

18.6 ± 0.4 (17.8–19.3)

3.07 ± 0.12 (2.87–3.27)

  99 keV/μm

17.5 ± 0.3 (16.8–18.2)

3.26 ± 0.13 (3.05–3.48)

(B) 1, 2 and 6 Fx

BED50 ± SE (90% CL) [Gy]

RBEmax ± SE (90% CL)

 Photonsa

244.9 ± 24.3 (208.2–293.3)

 

 Carbon ions

  16 keV/μm

76.3 ± 7.2 (66.0–92.0)

3.21 ± 0.44 (2.55–4.02)

  21 keV/μm

53.3 ± 3.7 (47.7–60.9)

4.59 ± 0.55 (3.73–5.57)

  36 keV/μm

39.5 ± 2.3 (36.0–44.6)

6.21 ± 0.71 (5.09–7.44)

  45 keV/μm

36.4 ± 1.8 (33.2–40.3)

6.73 ± 0.74 (5.55–8.00)

  66 keV/μm

20.3 ± 0.6 (19.4–21.3)

12.07 ± 1.24 (10.05–14.13)

  99 keV/μm

19.0 ± 0.6 (18.1–20.1)

12.87 ± 1.33 (10.71–15.08)

(C) 1, 2 and 6 Fx

α/β ± SE (90% CL) [Gy]

 

 Photonsa

2.8 ± 0.4 (2.2–3.5)

 

 Carbon ions

  16 keV/μm

6.9 ± 1.1 (5.2–8.9)

 

  21 keV/μm

9.8 ± 1.3 (7.7–12.2)

 

  36 keV/μm

14.6 ± 1.9 (11.4–18.2)

 

  45 keV/μm

12.8 ± 1.5 (10.3–16.4)

 

  66 keV/μm

44.3 ± 7.2 (33.8–60.4)

 

  99 keV/μm

30.8 ± 4.6 (23.9–40.9)

 
  1. aData obtained or derived from [10]
  2. bEstimated standard error, confidence limits could not be determined (see text)