Study | TD50 ± SE (90% CL) [Gy] | RBE ± SE (90% CL) |
---|---|---|
(A) 6 Fx | ||
Photonsa | 57.0 ± 2.0 (−)b | |
Carbon ions | ||
16 keV/μm | 39.1 ± 0.4 (38.2–40.0) | 1.46 ± 0.05 (1.37–1.55) |
21 keV/μm | 33.8 ± 0.6 (32.5–35.0) | 1.69 ± 0.07 (1.58–1.80) |
36 keV/μm | 28.7 ± 1.5 (−)b | 1.98 ± 0.12 (1.79–2.21) |
45 keV/μm | 26.9 ± 0.5 (25.7–28.1) | 2.12 ± 0.08 (1.98–2.26) |
66 keV/μm | 18.6 ± 0.4 (17.8–19.3) | 3.07 ± 0.12 (2.87–3.27) |
99 keV/μm | 17.5 ± 0.3 (16.8–18.2) | 3.26 ± 0.13 (3.05–3.48) |
(B) 1, 2 and 6 Fx | BED50 ± SE (90% CL) [Gy] | RBEmax ± SE (90% CL) |
Photonsa | 244.9 ± 24.3 (208.2–293.3) | |
Carbon ions | ||
16 keV/μm | 76.3 ± 7.2 (66.0–92.0) | 3.21 ± 0.44 (2.55–4.02) |
21 keV/μm | 53.3 ± 3.7 (47.7–60.9) | 4.59 ± 0.55 (3.73–5.57) |
36 keV/μm | 39.5 ± 2.3 (36.0–44.6) | 6.21 ± 0.71 (5.09–7.44) |
45 keV/μm | 36.4 ± 1.8 (33.2–40.3) | 6.73 ± 0.74 (5.55–8.00) |
66 keV/μm | 20.3 ± 0.6 (19.4–21.3) | 12.07 ± 1.24 (10.05–14.13) |
99 keV/μm | 19.0 ± 0.6 (18.1–20.1) | 12.87 ± 1.33 (10.71–15.08) |
(C) 1, 2 and 6 Fx | α/β ± SE (90% CL) [Gy] | |
Photonsa | 2.8 ± 0.4 (2.2–3.5) | |
Carbon ions | ||
16 keV/μm | 6.9 ± 1.1 (5.2–8.9) | |
21 keV/μm | 9.8 ± 1.3 (7.7–12.2) | |
36 keV/μm | 14.6 ± 1.9 (11.4–18.2) | |
45 keV/μm | 12.8 ± 1.5 (10.3–16.4) | |
66 keV/μm | 44.3 ± 7.2 (33.8–60.4) | |
99 keV/μm | 30.8 ± 4.6 (23.9–40.9) |