Fractionated carbon ion irradiations of the rat spinal cord: comparison of the relative biological effectiveness with predictions of the local effect model

Table 1 Dose levels and animal numbers used for the experiments

Water-equivalent depth [mm]	LET [keV/μm]	Dose levels [Gy]	Total number of animals
35	16	37^c, 38, 39, 40, 41, 45, 49^b	37
65	21	30, 32, 34, 36, 38, 40	30
80	36	25.5, 28.5^d, 31.5, 34.5	20
100^a	45	21.67, 24.49, 26.38, 28.26, 30.14, 32.97	30
120	66	14.5, 15.5, 16.5^f, 17.5^e, 18.5, 19.5, 20.5, 21.5, 22.5, 23.5, 24.5	55
127	99	15, 16, 17, 18^e, 19, 20	32
		controls	5

^aExperiment was performed at GSI, Darmstadt
^bOne animal died due to unknown reasons
^cTwo animals died during irradiation narcosis
^dOne animal died during irradiation narcosis
^eOne animal had to be excluded due to the development of mammary carcinomas (199 d and 200 d, respectively)
^fTwo animals had to be excluded due to the development of mammary carcinomas (158 d and 257 d, respectively)

ISSN: 1748-717X