Fig. 3

EUD plotted against the date of treatment start shows a typical learning curve with an initial increase followed by a plateau phase. EUD51 (EUD of PTV51) and EUD54 (EUD of PTV51) significantly increased from cohort A (first ten patients) to cohort B (remaining patients). Dmax as well as D2 to the optic nerve was significantly lower in cohort B compared to cohort A