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Table 4 Prognostic factors of visual acuity deterioration expressed in logMar from baseline value using linear regression on the 61 patients with available data on visual outcomes

From: Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas

 Bivariate analysesaMultivariate analysis a ∆
Estimationp-valueEstimationp-value
female (vs. male)0.046(0.164)0.781  
Age (years)0.010(0.005)0.0720.01 (0.004)0.008
Precancerous lesion nevus vs. de novo PAM vs. de novo0.146(0.180)
0. 365 (0.184)
0.423
0.052
0.243 (0.168)
0.285 (0.126)
0.153
0.028
Clinical stage
 T2 vs. T10.040(0.214)0.853  
 T3 vs. T10.524 (0.333)0.121  
Pathological stage
 pT2 vs. pT10.031(0.203)0.880  
 pT3 vs. pT10.723(0.375)0.059  
Multifocal0.768(0.202)< 0.0010.554 (0.157)< 0.001
Quandrangular involvement from 90 to 180° vs < 90°
> 180° vs < 90°
1.446(0.284) 0.246(0.146)0.098 < .0010.176 (0.115) 0.954 (0.237)0.130 < 0.001
Epithelioid type0.123(0.166)0.461  
Margins
 R1 vs.R00.041(0.181)0.8193  
 R2 vs.R0−0.302(0.251)0.2329  
Number of mitoses < 2−0.003(0.159)0.986  
Ulceration0.197(0.236)0.407  
Thickness < 2 mm0.147(0.248)0.556  
Diameter < 7 mm−.020(0.161)0.899  
Cryotherapy0.585(0.149)< 0.0010.461 (0.11)< 0.001
Mitomycin−0.302(0.170)0.082  
Follow-up time (years)0.007(0.013)0.607  
  1. aAdjusted on visual acuity at baseline
  2. associated R-square (percentage of explained variance) was 0.64
  3. Estimation expressed as estimated beta value and standard deviation from linear regression. For a qualitative parameter, a beta value of 0.3 logMAR was considered as significant deterioration in visual acuity
  4. Abbreviations: T: tumor, R0: complete resection, R1: microscopic resection, R2: macroscopic resection, HR: hazard ratio; CI: Confidence interval; vs.: versus, primary acquired melanosis (PAM)