Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas

Radiation Oncology

Table 3 prognostic factors of progression free survival

	Bivariate analyses		Multivariate analysis
	HR and 95% CI	p-value	HR and 95% CI	p-value
Female (vs. Male)	1.42 [0,70; 2.87]	0.332
Age	1.01 [0.98; 1.03]	0.574
Pre- cancerous lesion
nevus vs. de novo	0.18 [0.02; 1.47]	0.109
PAM vs. de novo	1.40[0.57;3.42]	0.465
Clinical stage
T2 vs. T1	3.01 [1.04; 8.73]	0.042	3.19 [1.04; 9.80]	0.042
T3 vs. T1	4.33 [1.88; 9.97]	0.001	4.75 [1.47; 15.28]	0.009
Pathological stage
pT2 vs. pT1	3.18 [1.16; 8.67]	0.024
pT3 vs. pT1	4.32 [1.82; 10.22]	0.001
Unifocal	0.87 [0.38;2.02]	0.751
Tumor epicenter caruncle and conjunctival folds + lids vs. bulbar	2.95[1.24;7.03]	0.015
Quadrangular involvement (degree)
90 to 180 vs. < 90	1.26 [0.46; 3.47]	0.648
> 180 vs. < 90	2.62 [0.75; 9.47]	0.132
Epithelioid type	3.29 [1.44; 7.52]	0.005	2.68 [1.12; 6.43]	0.027
Margins
R1 vs. R0	0.87 [0.42; 1.80]	0.704
R2 vs. R0	0.89 [0.11; 7.03]	0.909
Number of mitoses> = 2	1.09 [0.54; 2.18]	0.808
Ulceration	3.10 [1.26; 7.62]	0.014
Thickness > = 2 mm	1.06 [0.46; 2.46]	0.892
Diameter > = 7 mm	1.14 [0.57; 2.29]	0.705
Treatment
Mitomycin	1.10 [0.35; 3.47]	0.875
Cryotherapy	0.88 [0.37; 2.11]	0.775

^aHR for nevus not computed since no events in this stratum
Abbreviations: T: tumor, R0: complete resection, R1: microscopic resection, R2: macroscopic resection, HR: hazard ratio; CI: Confidence interval; vs.: versus, primary acquired melanosis (PAM)

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