Table 2 prognostic factors of local relapse
From: Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas
| Bivariate analyses | Multivariate analyses | |||
|---|---|---|---|---|
| HR and 95% CI | p-value | HR and 95% CI | p-value | |
| Female (vs Male) | 1.39 [0,63; 3.05] | 0.410 | ||
| Age | 0.99 [0.96; 1.02] | 0.556 | ||
| Precancerous lesiona | ||||
| PAM vs. de novo | 1.81 [0.69; 4.74] | 0.229 | ||
| Clinical stage | ||||
| T2 vs. T1 | 2.40 [0.74; 7.81] | 0.146 | 2.56 [0.80; 5.83] | 0.114 |
| T3 vs. T1 | 4.37[1.84; 10.42] | 0.001 | 7.32 [3.03; 17.67] | < 0.001 |
| Pathological stage | ||||
| pT2 vs. pT1 | 2.69 [0.95; 7.64] | 0.062 | ||
| pT3 vs. pT1 | 4.26[1.67; 10.88] | 0.002 | ||
| Unifocal | 0.56 [0.25; 1.28] | 0.169 | ||
| Tumor epicenter At caruncle and/or conjunctival folds and/or lids vs. bulbar | 4.85[1.62;14.53] | 0.005 | ||
| Quadrangular involvement (degree) | ||||
| 90 to 180 vs. < 90 | 1.97 [0.65; 5.96] | 0.404 | 2.15 [0.79; 5.83] | 0.133 |
| > 180 vs. < 90 | 4.92 [1.43; 6.92] | 0.028 | 4.00 [1.43; 11.16] | 0.008 |
| Epithelioid type | 2.66 [1.12; 6.29] | 0.026 | ||
| Margins | ||||
| R1 vs. R0 | 0.77 [0.35; 1.67] | 0.507 | ||
| R2 vs. R0 | 1.23[0.14; 10.74] | 0.854 | ||
| Number of mitoses> = 2 | 1.54 [0.72; 3.28] | 0.265 | ||
| Ulceration | 1.92 [0.65; 5.65] | 0.234 | ||
| Thickness > = 2 mm | 1.31 [0.47; 3.64] | 0.605 | ||
| Diameter > = 7 mm | 1.18 [0.55; 2.57] | 0.667 | ||
| Treatment | ||||
| Mitomycin | 1.41 [0.42; 4.78] | 0.406 | ||
| Cryotherapy | 0.68 [0.28; 1.68] | 0.581 | ||