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Table 2 prognostic factors of local relapse

From: Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas

 Bivariate analysesMultivariate analyses
HR and 95% CIp-valueHR and 95% CIp-value
Female (vs Male)1.39 [0,63; 3.05]0.410  
Age0.99 [0.96; 1.02]0.556  
Precancerous lesiona
 PAM vs. de novo1.81 [0.69; 4.74]0.229  
Clinical stage
 T2 vs. T12.40 [0.74; 7.81]0.1462.56 [0.80; 5.83]0.114
 T3 vs. T14.37[1.84; 10.42]0.0017.32 [3.03; 17.67]< 0.001
Pathological stage
 pT2 vs. pT12.69 [0.95; 7.64]0.062  
 pT3 vs. pT14.26[1.67; 10.88]0.002  
 Unifocal0.56 [0.25; 1.28]0.169  
Tumor epicenter At caruncle and/or conjunctival folds and/or lids vs. bulbar4.85[1.62;14.53]0.005  
Quadrangular involvement (degree)
 90 to 180 vs. < 901.97 [0.65; 5.96]0.4042.15 [0.79; 5.83]0.133
  > 180 vs. < 904.92 [1.43; 6.92]0.0284.00 [1.43; 11.16]0.008
Epithelioid type2.66 [1.12; 6.29]0.026  
Margins
 R1 vs. R00.77 [0.35; 1.67]0.507  
 R2 vs. R01.23[0.14; 10.74]0.854  
Number of mitoses> = 21.54 [0.72; 3.28]0.265  
Ulceration1.92 [0.65; 5.65]0.234  
Thickness > = 2 mm1.31 [0.47; 3.64]0.605  
Diameter > = 7 mm1.18 [0.55; 2.57]0.667  
Treatment
 Mitomycin1.41 [0.42; 4.78]0.406  
 Cryotherapy0.68 [0.28; 1.68]0.581  
  1. aHR for nevus not computed since no events in this stratum
  2. Abbreviations: T: tumor, R0: complete resection, R1: microscopic resection, R2: macroscopic resection, HR: hazard ratio; CI: Confidence interval; vs.: versus, primary acquired melanosis (PAM)