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Table 2 prognostic factors of local relapse

From: Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas

 

Bivariate analyses

Multivariate analyses

HR and 95% CI

p-value

HR and 95% CI

p-value

Female (vs Male)

1.39 [0,63; 3.05]

0.410

  

Age

0.99 [0.96; 1.02]

0.556

  

Precancerous lesiona

 PAM vs. de novo

1.81 [0.69; 4.74]

0.229

  

Clinical stage

 T2 vs. T1

2.40 [0.74; 7.81]

0.146

2.56 [0.80; 5.83]

0.114

 T3 vs. T1

4.37[1.84; 10.42]

0.001

7.32 [3.03; 17.67]

< 0.001

Pathological stage

 pT2 vs. pT1

2.69 [0.95; 7.64]

0.062

  

 pT3 vs. pT1

4.26[1.67; 10.88]

0.002

  

 Unifocal

0.56 [0.25; 1.28]

0.169

  

Tumor epicenter At caruncle and/or conjunctival folds and/or lids vs. bulbar

4.85[1.62;14.53]

0.005

  

Quadrangular involvement (degree)

 90 to 180 vs. < 90

1.97 [0.65; 5.96]

0.404

2.15 [0.79; 5.83]

0.133

  > 180 vs. < 90

4.92 [1.43; 6.92]

0.028

4.00 [1.43; 11.16]

0.008

Epithelioid type

2.66 [1.12; 6.29]

0.026

  

Margins

 R1 vs. R0

0.77 [0.35; 1.67]

0.507

  

 R2 vs. R0

1.23[0.14; 10.74]

0.854

  

Number of mitoses> = 2

1.54 [0.72; 3.28]

0.265

  

Ulceration

1.92 [0.65; 5.65]

0.234

  

Thickness > = 2 mm

1.31 [0.47; 3.64]

0.605

  

Diameter > = 7 mm

1.18 [0.55; 2.57]

0.667

  

Treatment

 Mitomycin

1.41 [0.42; 4.78]

0.406

  

 Cryotherapy

0.68 [0.28; 1.68]

0.581

  
  1. aHR for nevus not computed since no events in this stratum
  2. Abbreviations: T: tumor, R0: complete resection, R1: microscopic resection, R2: macroscopic resection, HR: hazard ratio; CI: Confidence interval; vs.: versus, primary acquired melanosis (PAM)