Fig. 1
From: Mechanisms of different response to ionizing irradiation in isogenic head and neck cancer cell lines
Radiosensitivity and chemosensitivity of isogenic head and neck squamous cell carcinoma cells with different radiosensitivity. a Schematic representation of the establishment of isogenic radioresistant FaDu-RR cells from parental FaDu cells by repeated exposure to one series (FaDu-R1), two series (FaDu-R2), and four series (FaDu-RR) of ionizing radiation; b Surviving fraction of isogenic parental FaDu, radioresistant FaDu-R1, FaDu-R2, and FaDu-RR, and radiosensitive 2A3 cells fitted to LQ model. Symbols are mean values (AM) ± standard error of the mean (SEM) from three independent experiments. The dashed line indicates the surviving fraction of 0.1 (D10 value). c Clonogenic survival of isogenic cells after exposure to (c) cisplatin (CDDP), d oxaliplatin (Oxa) and (e) bleomycin (BLM). The dotted line indicates a surviving fraction of 0.5. Symbols are AM ± SEM, n = 3