Early detection of subclinical left ventricular dysfunction after breast cancer radiation therapy using speckle-tracking echocardiography: association between cardiac exposure and longitudinal strain reduction (BACCARAT study)

Table 5 Associations between cardiac radiation doses and subclinical LV dysfunction (GLS reduction > 10%) after RT

	Univariate analysis		Multivariate analysis^a
	OR (95% CI)	p-value	OR (95% CI)	p-value
Laterality of BC (left vs. right)	1.41 (0.45–4.42)	0.55	–	–
Heart
Dmean (Gy)	1.37 (1.01–1.86)	0.04	1.21 (0.87–1.71)	0.26
D2 (Gy)	1.02 (0.99–1.05)	0.13	–	–
V20 (%)	1.20 (1.01–1.43)	0.04	1.13 (0.93–1.36)	0.23
Left Ventricle
Dmean (Gy)	1.14 (1.01–1.28)	0.03	1.09 (0.96–1.25)	0.17
D2 (Gy)	1.02 (0.99–1.04)	0.22	–	–
V20 (%)	1.08 (1.01–1.14)	0.02	1.05 (0.99–1.12)	0.12

^aAdjusted for BMI, hypercholesterolemia and endocrine therapy; p-values in bold are significant (<0.05)

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