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Table 4 Non radiation factors associated with subclinical LV dysfunction (GLS reduction > 10%) after RT

From: Early detection of subclinical left ventricular dysfunction after breast cancer radiation therapy using speckle-tracking echocardiography: association between cardiac exposure and longitudinal strain reduction (BACCARAT study)

 

OR (95% CI)

p-value

Age (in years)

0.98 (0.93–1.04)

0.52

BMI (in Kg.m-2)

1.15 (1.02–1.30)

0.02a

Smoking

 Former vs. No

0.59 (0.20–1.68)

0.31

 Current vs No

1.98 (0.57–6.91)

0.28

Hypertension

1.03 (0.37–2.89)

0.95

Diabetes

1.76 (0.28–11.19)

0.55

Hypercholesterolemia

1.95 (0.74–5.15)

0.18a

Endocrine therapy

3.20 (1.02–10.10)

0.04a

 Anti-aromatase

4.52 (1.32–15.53)

0.02

 Tamoxifen

2.05 (0.57–7.41)

0.27

RT protocol (hypofractionnated vs. standard)

0.91 (0.33–2.51)

0.84

  1. BMI Body Mass Index, avariables with p-value < 0.20 are considered for adjustment in multivariate analysis for the relationship between cardiac exposure and GLS reduction > 10%