Early detection of subclinical left ventricular dysfunction after breast cancer radiation therapy using speckle-tracking echocardiography: association between cardiac exposure and longitudinal strain reduction (BACCARAT study)

Table 3 Echocardiographic measurements at baseline and 6 months after RT

	All BC patients N = 79	Left-sided BC patients N = 64	Right-sided BC patients N = 15
LVEF (in %)
Before RT	62 ± 7	61 ± 7	64 ± 8
RT + 6 months	60 ± 9	60 ± 9	63 ± 8
p-value	0.07	0.09	0.51
GLS (in %)
Before RT	-16.1 ± 2.7	−16.0 ± 2.6	−16.2 ± 2.8
RT + 6 months	−15.1 ± 3.2	−15.0 ± 3.0	− 15.2 ± 4.0
p-value	0.01	0.02	0.26
Patients with GLS reduction > 10% after RT	37 (47%)	31 (48%)	6 (40%)
GLSR (in s⁻¹)
q Before RT	−0.93 ± 0.14	−0.92 ± 0.15	−0.98 ± 0.11
RT + 6 months	−0.98 ± 0.21	−0.96 ± 0.16	− 1.06 ± 0.34
p-value	0.09	0.15	0.37

LVEF Left Ventricular Ejection Fraction, GLS Global Longitudinal Strain, GLSR Global Longitudinal Strain Rate, BC Breast Cancer, RT Radiotherapy; p-values in bold are significant (<0.05)

ISSN: 1748-717X