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Table 2 Univariate analysis of risk factors for progression free survival (PFS) and overall survival (OS) in 91 patients

From: The preliminary results of proton and carbon ion therapy for chordoma and chondrosarcoma of the skull base and cervical spine

Prognostic factors 2-year PFS (%) [95% CI]P value2-year OS (%) [95% CI]P value
Age (yeaars)≤3864.1(7.5)0.14281.8(6.3)0.130
 >3889.6(5.0) 92.5(4.3) 
GenderFemale82.8(6.6)0.51388.9(5.3)0.686
 Male72.7(6.5) 86.5(5.2) 
KPS≥9080.1(4.8)0.02990.8(3.6)0.008
 8053.0(15.5) 59.7(15.9) 
Critical organ compressionYes71.1(5.8)0.01283.4(4.9)0.048
 No95.7(4.3) 100 
Cranial nerve injuryYes71.4(5.8)0.01183.5(4.8)0.043
 No95.7(4.3) 100 
HistologyChordoma73.5(5.5)0.13285.9(4.4)0.340
 Chondrosarcoma92.9(6.9) 92.9(6.9) 
GTV≤60 cc84.9(5.0)0.00493.9(3.4)<0.001
 >60 cc59.7(9.5) 73.2(8.8) 
Recurrent diseaseYes73.8(6.9)0.82882.7(6.0)0.260
 No80.4(6.4) 92.5(4.2) 
Re-radiotherapyYes41.3(15.7)0.01550.3(15.5)<0.001
 No82.8(4.6) 93.8(3.0) 
Surgery times181.1(6.1)0.60987.7(5.2)0.654
 ≥271.5(7.3) 86.3(5.7) 
RTProton1000.691000.489
 Proton+carbon74.2(8.4) 84.6(7.1) 
 Carbon75.6(6.3) 87.3(5.1)