Dose distribution of intensity-modulated proton therapy with and without a multi-leaf collimator for the treatment of maxillary sinus cancer: a comparative effectiveness study

Sugiyama, Soichi; Katsui, Kuniaki; Tominaga, Yuki; Waki, Takahiro; Katayama, Norihisa; Matsuzaki, Hidenobu; Kariya, Shin; Kuroda, Masahiro; Nishizaki, Kazunori; Kanazawa, Susumu

doi:10.1186/s13014-019-1405-y

Table 4 ROI-_D2%, ROI-_mean, and difference in OARs and PRVs in IMPT planning without and with an MLC

From: Dose distribution of intensity-modulated proton therapy with and without a multi-leaf collimator for the treatment of maxillary sinus cancer: a comparative effectiveness study

		Mean (Gy)	Range (Gy)	Difference (Gy)	p value	* p<0.05			Mean (Gy)	Range (Gy)	Difference (Gy)	p value	* p<0.05
ROI-_D2%, difference (without an MLC - using an MLC) ROI-_D2%, difference (without an MLC - using an MLC)
Optic chiasm	MLC-	18.04	56.8-0.08	0.78	0.096		Brainstem	MLC-	5.75	17.82-0.39	0.27	0.034	*
Optic chiasm	MLC+	17.27	56.52-0.06					MLC+	5.48	15.65-0.4
Pituitary gland	MLC-	23.13	56.03-2.31	-0.05	0.99
Pituitary gland	MLC+	23.19	55.86-1.63
IS Optic nerve	MLC-	50.06	65.59-1.80	0.48	0.016	*	CS Optic nerve	MLC-	27.21	58.71-2.23	1.92	0	*
IS Optic nerve	MLC+	49.58	65.35-1.75					MLC+	25.29	59.27-0.82
IS Posterior retina	MLC-	38.63	52.64-2.51	-0.63	0.049	*	CS Posterior retina	MLC-	12.84	47.61-0	1.05	0	*
IS Posterior retina	MLC+	39.27	51.95-2.81					MLC+	11.79	47.61-0.01
IS Eyeball	MLC-	35.86	50.25-2.23	-1.1	0.003	*	CS Eyeball	MLC-	11.65	44.99-0	0.67	0.005	*
IS Eyeball	MLC+	36.95	50.18-2.46					MLC+	10.98	46.19-0.01
IS Lens	MLC-	6.23	9.92-0.22	0.38	0.006	*	CS Lens	MLC-	2.29	6.54-0	0.51	0	*
IS Lens	MLC+	5.85	9.85-0.11					MLC+	1.79	7.06-0
IS Lacrimal gland	MLC-	13.73	46.29-0.05	1.5	0.001	*	CS lacrimal gland	MLC-	2.1	29.07-0	0.41	0.005	*
IS Lacrimal gland	MLC+	12.22	46.32-0.01					MLC+	1.69	28.84-0
IS Parotid gland	MLC-	13.91	69.24-0	3.76	0	*	CS Parotid gland	MLC-	0.32	3.89-0	0.07	0.345	*
IS Parotid gland	MLC+	10.16	68.66-0					MLC+	0.25	2.93-0
IS Cochlea	MLC-	2.65	40.22-0	0.27	0.02	*	CS Cochlea	MLC-	2.45	16.69-0	0.14	0.044	*
IS Cochlea	MLC+	2.38	44.62-0					MLC+	2.31	15.62-0
ROI-_mean, difference (without an MLC - using an MLC) ROI-_mean, difference (without an MLC - using an MLC)
Optic chiasm	MLC-	8.2	32.29-0.02	0.7	0	*	Brainstem	MLC-	0.82	4.01-0.04	0.09	0	*
Optic chiasm	MLC+	7.5	31.29-0.01					MLC+	0.73	4.04-0.04
Pituitary gland	MLC-	15.1	45.19-1.25	0.62	0.038	*
Pituitary gland	MLC+	14.49	45.35-0.94
IS Optic nerve	MLC-	27.66	54.82-0.35	1.04	0	*	CS Optic nerve	MLC-	11.11	38.99-0.36	1.66	0	*
IS Optic nerve	MLC+	26.62	54.88-0.25					MLC+	9.45	38.06-0.10
IS Posterior retina	MLC-	15.77	28.02-0.35	0.41	0.134		CS Posterior retina	MLC-	3.61	19.11-0	0.54	0	*
IS Posterior retina	MLC+	15.36	28.70-0.39					MLC+	3.07	19.35-0
IS Eyeball	MLC-	11.65	23.55-0.28	0.2	0.282		CS Eyeball	MLC-	2.96	13.31-0	0.48	0	*
IS Eyeball	MLC+	11.45	23.99-0.29					MLC+	2.48	13.31-0
IS Lens	MLC-	2.91	4.09-0.07	0.31	0.004	*	CS Lens	MLC-	1.16	4.27-0	0.39	0	*
IS Lens	MLC+	2.6	4.30-0.03					MLC+	0.78	3.49-0
IS Lacrimal gland	MLC-	6.49	30.92-0.01	0.75	0.001	*	CS Lacrimal gland	MLC-	0.75	9.84-0	0.23	0.008	*
IS Lacrimal gland	MLC+	5.75	30.89-0					MLC+	0.51	7.81-0
IS Parotid gland	MLC-	2.43	21.85-0	0.48	0	*	CS Parotid gland	MLC-	0.02	0.32-0	0.02	0.068
IS Parotid gland	MLC+	1.95	20.58-0					MLC+	0.01	0.18-0
IS Cochlea	MLC-	1.02	17.35-0	0.16	0.006	*	CS Cochlea	MLC-	0.87	6.17-0	0.13	0.008	*
IS Cochlea	MLC+	0.86	17.22-0					MLC+	0.74	5.66-0

ROI region of interest, ROI-_D2% D2% of region of interest, ROI-_mean mean doses of the region of interest, OAR organ at risk, PRV planning organ at risk volume, MLC multi-leaf collimator, IS ipsilateral side, CS contralateral side
* p < 0.05 Significant difference

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