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Table 2 Univariate and multivariate analysis of risk factors in training cohort

From: Development and validation of a risk prediction model for radiotherapy-related esophageal fistula in esophageal cancer

Factors Univariate Multivariate
P OR (95.0% CI) P OR (95.0% CI)
Age (years)
  < 60 0.944 1.015 (0.673–1.529)   
  ≥ 60     
ECOG PS
  ≤ 2 < 0.001 7.922 (3.828–16.396) < 0.001 5.165 (2.180–12.242)
  ≥ 3     
BMI (kg/m2)
  < 18.5 < 0.001 1.00(reference) 0.001 1.00(reference)
 18.5–23.9   0.283 (0.138–0.583)   0.371 (0.164–0.837)
 24–27.9   0.154 (0.066–0.360)   0.176 (0.065–0.480)
  ≥ 28   0.038 (0.010–0.150)   0.059 (0.012–0.287)
History of Smoking
 No 0.137 1.381 (0.903–2.112)   
 Yes     
History of diabetes
 No 0.638 0.843 (0.414–1.716)   
 Yes     
T stage
 T1–3 < 0.001 2.853 (1.763–4.617) 0.018 2.123 (1.137–3.965)
 T4     
N stage
 N0–1 < 0.001 2.355 (1.527–3.629) 0.003 2.489 (1.377–4.499)
 N2–3     
Longitudinal length of lesions 0.020 1.096 (1.015–1.185) 0.246 1.064 (0.958–1.181)
General type
 Medullary type 0.409 1.00(reference)   
 Mushroom type   1.458 (0.810–2.627)   
 Ulcerative type   1.607 (0.936–2.760)   
 Constrictive type   0.992 (0.448–2.196)   
 Cavity type   0.941 (0.278–3.182)   
Re-radiotherapy
 No < 0.001 6.262 (2.682–14.620) < 0.001 10.392 (3.491–30.938)
 Yes     
Single dose of radiation (Gy)
  ≤ 2 1.000 1.000 (0.404–2.478)   
  > 2     
Chemotherapy
 No 0.500 1.166 (0.746–1.821)   
 Yes     
Chemotherapy
 0 line 0.307 1.00(reference)   
 1 line   1.072 (0.678–1.695)  
 2 line   1.990 (0.841–4.710)  
 3 line and more   2.367 (0.496–11.306)   
Taxol chemotherapy
 No 0.031 1.592 (1.043–2.428) 0.128 1.524 (0.886–2.622)
 Yes     
Serum cholesterol (mmol/l)
  < 4.40 0.029 0.819 (0.656–1.024) 0.056 0.557 (0.305–1.016)
  ≥ 4.40     
Serum albumin (g/dl)
  < 3.5 0.495 0.936 (0.887–0.988)   
  ≥ 3.5