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Table 3 Univariate and multivariate analysis of the overall survival prognostic factors (n = 83)

From: Salvage treatment for lymph node recurrence after radical resection of esophageal squamous cell carcinoma

Variable

Univariate analysis

multivariate analysis

No.

χ2

P

HR((95%CI)

P

Gender

 Male

67

1.689

.194

  

 Female

16

  

.584(.170–2.008)

.394

Age

 ≥ 63 years

43

1.782

.182

  

 <63 year

40

  

2.345 (1.068–5.147)

.034

Primary tumor location

 Cervix+Upper thorax

6

2.061

.357

  

 Middle thorax

36

    

 Lower thorax

41

    

Radical surgery

 Ivor-Lewis surgery

48

.385

.535

  

 Sweet surgery

26

    

pT

 pT1 + 2

35

.036

.850

  

 pT3 + 4

48

    

pN

 pN0

40

1.769

.184

  

 pN+

43

  

1.339(.622–2.879)

.456

pStagea(AJCC 7th edition)

 I + II

49

1.456

.228

  

 III

34

    

Interval to recurrence

 >6 months

20

.001

.980

  

 ≤ 6 months

63

    

Recurrent lymph node size

 >5.5 cm3

41

1.146

.284

  

 ≤ 5.5 cm3

42

    

Number of recurrent nodes

 Multiple

64

.607

.436

  

 Single

19

    

Region of recurrent nodes

 Multiple

25

1.104

.293

  

 Single

58

    

Lymph node recurrence site

 Supraclavicular

6

4.586

.101

  

 Mediastinal

50

  

1.839(.430–7.856)

.411

 Abdominal

2

  

3.123 (.262–37.160)

.367

Salvage Treatments

 RT

41

.322

.570

  

 CCRTb

35

    

Radiation technique

 VAMTc

74

.248

.618

  

 3DCRTd

9

    

Concurrent chemotherapy regimen

 platinum

18

.801

.371

  

 fluorouracil

15

    

Radiation dose

 ≥ 60Gy

46

.020

.888

  

 <60Gy

37

    

Tumor Response

 CR + PR

68

.331

.565

  

 SD + PD

15

    
  1. apostoperative stage of esophageal cancer
  2. bconcurrent chemoradiotherapy
  3. cvolumetric modulated arc therapy
  4. dthree-dimensional conformal radiation therapy