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Table 1 Patient characteristics

From: Dose-volume analysis of predictors for acute anal toxicity after radiotherapy in prostate cancer patients

 

Training group (N = 248 cases)

Validation group (N = 99 cases)

Factors

NAAT

AAT

P

NAAT

AAT

P

Age (%)

 46-68ys

72 (55.8)

57 (44.2)

0.117

44 (75.9)

14 (24.1)

0.067

 68-88ys

78 (65.5)

41 (34.5)

24 (58.5)

17 (41.5)

T stage (%)

 1~2

36 (56.3)

28 (43.7)

0.789

21 (67.7)

10 (32.3)

0.933

 3~4

114 (62.0)

70 (38.0)

45 (69.2)

20 (30.8)

N stage (%)

 0

92 (64.3)

51 (35.7)

0.148

40 (65.6)

21 (34.4)

0.375

 1

58 (55.2)

47 (44.8)

26 (74.3)

9 (25.7)

M stage (%)

 0

90 (60.4)

59 (39.6)

0.974

48 (69.6)

21 (30.4)

0.775

 1

60 (60.6)

39 (39.4)

20 (66.7)

10 (33.3)

Clinical stage (%)

 I~II

23 (54.8)

19 (45.2)

0.753

18 (66.7)

9 (33.3)

0.880

 III~IV

127 (61.7)

79 (38.3)

50 (69.4)

22 (30.6)

GS group (%)

 6~7

66 (64.7)

36 (35.3)

0.256

25 (80.6)

6 (19.4)

0.074

 8~10

84 (57.5)

62 (42.5)

40 (62.5)

24 (37.5)

TPSA before treatment (%)

  < 20 ng/mL

22 (59.5)

15 (40.5)

0.890

40 (62.5)

24 (37.5)

0.226

  ≥ 20 ng/mL

128 (60.7)

83 (39.3)

19 (76.0)

6 (24.0)

TPSA before RT (%)·

  < 20 ng/mL

119 (60.1)

79 (39.9)

0.806

61 (67.0)

30 (33.0)

0.407

  ≥ 20 ng/mL

31 (62.0)

19 (28.0)

5 (83.3)

1 (16.7)

RT type (%)

 IMRT/VMAT

23 (67.6)

11 (32.4)

0.358

5 (50.0)

5 (50.0)

0.179

 IMRT/VMAT-IGRT

127 (59.3)

87 (40.7)

63 (70.8)

26 (29.2)

RT modality (%)

 Conventional fraction

126 (62.1)

77 (37.9)

0.278

46 (66.7)

23 (33.3)

0.511

 Hypo-fraction

24 (53.3)

21 (46.7)

22 (73.3)

8 (26.7)

Surgery (%)

 No

94 (61.4)

59 (38.6)

0.697

31 (62.0)

19 (38.0)

0.483

 Yes

56 (58.9)

39 (41.1)

33 (68.8)

15 (31.3)

Hormonal treatment duration (%)

  < 2 years

23 (54.8)

19 (45.2)

0.405

17 (63.0)

10 (37.0)

0.730

  ≥ 2 years

127 (61.7)

79 (38.3)

48 (66.7)

24 (33.3)

Hemorrhoid (%)

 NO

95 (87.2)

14 (12.8)

< 0.001

39 (83.0)

8 (17.0)

0.004

 Yes

55 (39.6)

84 (60.4)

29 (55.8)

23 (44.2)

  1. Abbreviations: GS Gleason score; TPSA total prostate-specific antigen; RT radiation therapy