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Table 2 Sarcopenia endpoints (n = 61)

From: Skeletal muscle mass correlates with increased toxicity during neoadjuvant radiochemotherapy in locally advanced esophageal cancer: A SAKK 75/08 substudy

Variable

Before induction therapy (baseline)

Before RC(I)T

Before surgery

Change between baseline and surgery (p-value*)

Skeletal muscle surface (cm2)

160.1 (72.8, 211.4)

144.9 (66.5, 198.0)

144.4 (61.4, 187.0)

−14.6 (p < 0.0001)

Total adipose tissue (cm2)

294.9 (24.1, 823.6)

292.4 (29.9, 841.1)

285.7 (64.1, 756.6)

−10.7 (p = 0.041)

L3 skeletal muscle index (cm2/ m2)

52.2 (26.7, 75.8)

47.3 (24.4, 66.9)

46.5 (22.6, 67.1)

−5.0 (p < 0.0001)

Sarcopenia

29.5%

49.2%

63.9%

+ 34.4% (p < 0.0001)

  1. RC(I)T Radiochemo (immuno) therapy. Values are depicted as median (range). Sarcopenia was defined according to established sex-specific cut-off values [21]. *Mc Nemar test for categorical variables and Wilcoxon rank-sum test for continuous variables