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Table 3 Multivariate analyses for overall survival

From: Patterns of brain metastasis immediately before prophylactic cranial irradiation (PCI): implications for PCI optimization in limited-stage small cell lung cancer

Variable Univariate Multivariate
HR (95% CI) P HR (95% CI) P
Age at diagnosis 1.022 (0.986–1.059) 0.235   
Gender 1.725 (0.728–4.086) 0.215   
Smoking status 1.205 (0.614–2.366) 0.588   
T stage (1–2 vs 3–4) 2.247 (1.215–4.157) 0.010* 2.610 (1.364–4.993) 0.004*
N stage (0–2 vs 3) 1.513 (0.771–2.968) 0.229 2.160 (1.056–4.417) 0.035*
CRT-D (months) 1.219 (1.024–1.451) 0.026* 1.227 (1.026–1.466) 0.025*
Variable HR (95% CI) P HR (95% CI) P
Age at diagnosis 1.022 (0.986–1.059) 0.235   
Gender 1.725 (0.728–4.086) 0.215   
Smoking status 1.205 (0.614–2.366) 0.588   
T stage (1–2 vs 3–4) 2.247 (1.215–4.157) 0.010* 2.637 (1.348–5.158) 0.005*
N stage (0–2 vs 3) 1.513 (0.771–2.968) 0.229 2.016 (0.967–4.202) 0.061
pre-PCI BM 4.336 (2.421–7.765) <  0.001* 4.143 (2.318–7.406) <  0.001*
  1. Abbreviation: HR Hazard ratio, CI Confidence interval, PCI Prophylactic cranial irradiation, BM Brain metastasis, CRT-D Chemoradiotherapy duration, pre-PCI BM Brain metastasis immediately before PCI. Age and CRT-D as continuous variables. Cox regression was employed for multivariate analysis. (*) statistically significant