Adjuvant radiotherapy improves progression-free survival in intracranial atypical meningioma

Radiation Oncology

Table 2 Uni- and multivariable analyses of progression-free survival. P-values ≤0.05 were defined as statistically significant (*). Tumor localization in multivariable analysis was performed according to the CLASS algorithm (and not as “skullbase vs non-skullbase”) because this information is already included in the CLASS algorithm

	Univariable			Multivariable
	p	HR	95% CI	p	HR	95% CI
Adjuvant radiotherapy (Intervention vs. control)	0.009^*	0.204	0.062–0.668	0.041^*	0.192	0.039–0.932
Sex (Male vs. female)	0.014^*	0.441	0.229–0.850	0.422	0.666	0.247–1.796
Simpson resection grade¹⁴ (Grade IV/V vs. Grade I/II/III)	0.009^*	1.488	1.106–2.001	0.032^*	1.655	1.043–2.626
Patient age at first diagnosis (> median vs. ≤ median)	0.465	1.278	0.662–2.468	0.750	1.175	0.436–3.163
Pretherapeutic tumor volume (> median vs. ≤ median)	0.908	0.96	0.478–1.928	0.773	1.181	0.380–3.669
Intracranial tumor localization (CLASS moderate/high risk vs. low risk)	0.301	1.184	0.860–1.630	0.614	1.163	0.647–2.093
Intracranial tumor localization (non-skull base vs. skull base)	0.5	0.998	0.991–1.004

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