From: Adjuvant radiotherapy improves progression-free survival in intracranial atypical meningioma
Characteristics | Total n = 99 | Intervention n = 19 | Control n = 80 | p-value |
---|---|---|---|---|
Median (Min/Max) | Median (Min/Max) | Median (Min/Max) | ||
Patient age at first diagnosis (years) | 59 | 59 | 59 | 0.49 |
(22/84) | (26/75) | (22/84) | ||
Pretherapeutic tumor volume (cm3) | 29.7 | 47.1 | 26.1 | 0.16 |
(0.8/153.9) | (12.6/90.2) | (0.8/153.9) | ||
n (%) | n (%) | n (%) | ||
Sex | ||||
Male | 42 (42.4) | 8 (42.1) | 34 (42.5) | 0.98 |
Female | 57 (57.6) | 11 (57.9) | 46 (57.5) | |
Tumor location | ||||
Convexity | 36 (36.4) | 7 (36.8) | 29 (36.3) | 0.91 |
Olfactory groove / Planum sphenoidale | 4 (4.0) | 0 (0.0) | 4 (5) | |
Lateral sphenoid wing / Temporal bone | 6 (6.1) | 2 (10.5) | 4 (5) | |
Parasagittal / Falx | 23 (23.2) | 4 (21.1) | 19 (23.8) | |
Cerebellopontine angle | 3 (3.0) | 1 (5.3) | 2 (2.5) | |
Petroclival | 1 (1.0) | 0 (0) | 1 (1.3) | |
Medial sphenoid wing / Clinoid / Orbital | 17 (17.2) | 4 (21.1) | 13 (16.3) | |
Tuberculum sellae | 3 (3.0) | 0 (0) | 3 (3.8) | |
Cavernous sinus | 0 (0.0) | 0 (0) | 0 (0) | |
Tentorial | 6 (6.1) | 1 (5.3) | 5 (6.3) | |
Foramen magnum | 0 (0.0) | 0 (0) | 0 (0) | |
Optic nerve sheath | 0 (0.0) | 0 (0) | 0 (0) | |
Simpson grade | ||||
1 | 24 (24.2) | 5 (26.3) | 19 (23.8) | 0.39 |
2 | 35 (35.4) | 4 (21.1) | 31 (38.8) | |
3 | 1 (1.0) | 0 (0) | 1 (1.3) | |
4 | 11 (11.1) | 4 (21.1) | 7 (8.8) | |
5 | 1 (1.0) | 1 (5) | 0 (0) | |
Not documented | 27 (27.3) | 5 (26.3) | 22 (27.5) | |
Salvage therapies | ||||
No recurrence | 58 (58.6) | 16 (84.2) | 42 (52.5) | |
Resection | 3 (3.0) | 0 (0.0) | 3 (3.8) | |
Radiotherapy | 19 (19.2) | 2 (10.5) | 17 (21.3) | |
Resection and Radiotherapy | 19 (19.2) | 1 (5.3) | 18 (22.5) | |
Fractionation scheme | ||||
Not irradiated | 80 (80.8) | 0 (0) | 80 (100) | |
Normofractionation (1.8–2.2 Gy) | 17 (17.1) | 17 (89.5) | 0 (0) | |
Hypofractionation (> 2.2–5 Gy) | 1 (1) | 1 (5.3) | 0 (0) | |
SRS (> 5 Gy) | 1 (1) | 1 (5.3) | 0 (0) |