| | |
Group 1 (n = 19)
|
Group 2 (n = 44)
| | |
|---|
|
Before RT
|
After RT
|
3 year
| |
Before RT
|
After RT
|
3 year
|
|---|
|
n
|
Md
|
(IQR)
|
Md
|
(IQR)
|
Md
|
(IQR)
|
p1
|
p2
|
n
|
Md
|
(IQR)
|
Md
|
(IQR)
|
Md
|
(IQR)
|
p1
|
p2
|
|---|
|
LV measurements
|
|
LVEDD (mm)
|
19
|
46.0
|
(44.0–48.0)
|
45.0
|
(44.0–50.0)
|
46.0
|
(42.0–50.0)
|
0.513
|
0.446
|
44
|
46.0
|
(44.0–47.0)
|
46.0
|
(43.3–47.0)
|
45.0
|
(43.0–47.0)
|
0.904
|
0.654
|
|
LVESD (mm)
|
19
|
31.0
|
(29.0–34.0)
|
32.0
|
(28.0–34.0)
|
31.0
|
(29.0–35.0)
|
0.854
|
0.954
|
44
|
31.0
|
(29.0–32.8)
|
30.5
|
(29.0–31.8)
|
30.0
|
(29.0–32.0)
|
0.781
|
0.896
|
|
IVS (mm)
|
19
|
10.0
|
(9.0–11.0)
|
11.0
|
(10.0–12.0)
|
11.0
|
(10.0–11.0)
|
0.036
|
0.157
|
44
|
10.0
|
(9.0–11.0)
|
10.0
|
(9.0–11.0)
|
10.0
|
(9.0–11.0)
|
0.378
|
0.775
|
|
PW (mm)
|
19
|
10.0
|
(9.0–11.0)
|
11.0
|
(10.0–12.0)
|
9.0
|
(10.0–11.0)
|
0.030
|
0.434
|
44
|
10.0
|
(9.0–11.0)
|
10.0
|
(9.3–11.0)
|
9.0
|
(8.3–10.0)
|
0.144
|
0.028
|
|
LV systolic function
|
|
LV EF (%)
|
19
|
62.0
|
(56.0–65.0
|
61.0
|
(58.0–65.0)
|
60.0
|
(57.0–63.0)
|
0.886
|
0.144
|
44
|
62.0
|
(60.0–65.0
|
63
|
(59.3–65.0)
|
61.5
|
(57.0–63.0)
|
1.000
|
0.092
|
|
GLS (%)
|
17
|
─17.0
|
(─20.5-─16.0)
|
─17.0
|
(─19.5-─15.5)
|
─16.0
|
(─18.5-─14.0)
|
0.373
|
0.006
|
44
|
─18.0
|
(─19.8-─15.0)
|
─17.0
|
(─20.0-─15.0)
|
─18.0
|
(─20.0-─16.0)
|
0.159
|
0.762
|
|
LV diastolic function
|
|
Mitral inflow E (cm/s)
|
19
|
73.5
|
(66.2–81.9)
|
66.1
|
(57.2–79.0)
|
66.2
|
(61.7–78.4)
|
0.113
|
0.106
|
44
|
75.4
|
(63.8–87.3)
|
72.4
|
(60.3–80.0)
|
71.4
|
(62.0–89.0)
|
0.139
|
0.242
|
|
Ee’ ratio
|
19
|
8.3
|
(6.8–10.2)
|
7.8
|
(7.1–11.1)
|
8.7
|
(7.1–10.2)
|
0.701
|
0.347
|
44
|
9.5
|
(7.7–11.4)
|
9.3
|
(7.1–10.2)
|
8.9
|
(7.7–11.0)
|
0.076
|
0.337
|
|
RV function
|
|
TAPSE (mm)
|
17
|
24.0
|
(21.0–28.0)
|
21.0
|
(18.5–24.5)
|
22.0
|
(20.5–27.5)
|
0.021
|
0.363
|
42
|
24.5
|
(20.8–27.3)
|
22.0
|
(19.0–26.0)
|
24.0
|
(20.0–26.0)
|
0.001
|
0.119
|
|
TR gradient (mmHg)
|
12
|
21.0
|
(18.3–26.0)
|
20.5
|
(17.3–24.0)
|
23.5
|
(19.3–28.5)
|
0.351
|
0.381
|
35
|
21.0
|
(17.0–25.0)
|
22.0
|
(19.0–24.0)
|
24.0
|
(20.0–29.0
|
0.811
|
< 0.001
|
|
Tissue characterization
|
|
scIBS (dB)
|
17
|
15.5
|
(12.5–21.3)
|
19.5
|
(13.7–25.1)
|
23.3
|
(20.1–25.8)
|
0.031
|
< 0.001
|
44
|
17.6
|
(14.1–22.1)
|
19.6
|
(16.3–24.2)
|
20.3
|
(18.8–22.8)
|
0.007
|
0.002
|
|
rcIBS (dB)
|
17
|
18.7
|
(14.8–21.8)
|
22.9
|
(20.1–25.9)
|
23.5
|
(19.1–27.0)
|
0.011
|
0.013
|
44
|
21.1
|
(17.1–24.6)
|
23.0
|
(18.0–26.9)
|
24.1
|
(20.3–27.0)
|
0.208
|
0.021
|
|
pcIBS (dB)
|
17
|
10.3
|
(7.6–11.9)
|
9.2
|
(8.2–12.1)
|
9.4
|
(6.5–13.1)
|
0.579
|
0.854
|
43
|
9.8
|
(6.8–13.9)
|
10.3
|
(8.3–12.5)
|
10.5
|
(6.8–13.4)
|
0.888
|
0.959
|
- TGF-β1 Transforming growth factor beta 1, RT Radiotherapy, Md Median, IQR Interquartile range, p1 p-value for before to after RT, p2 p-value for before to 3 years after RT, LV Left ventricle, LVEDD Left ventricle end diastolic diameter, LVESD Left ventricle end systolic diameter, IVS Interventricular septum thickness, PW Posterior wall thickness, EF Ejection fraction, GLS Global longitudinal strain, Mitral inflow E First peak of diastole, Ee’ Pulsed tissue doppler e’ velocity, RV Right ventricle, TAPSE Tricuspid annular plane systolic excursion, TR gradient Tricuspid regurgitation maximal gradient, scIBS Septal calibrated integrated backscatter, rcIBS Right ventricle integrated backscatter, pcIBS Posterior wall of left ventricle integrated backscatter
