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Table 2 Dose parameters for organs at risk, i.e. average dose (in Gy) to heart, LADCA, and left lung for 20 patients with left-sided breast cancer comparing t-IMRT and t-VMAT, both in DIBH-technique

From: Left breast irradiation with tangential intensity modulated radiotherapy (t-IMRT) versus tangential volumetric modulated arc therapy (t-VMAT): trade-offs between secondary cancer induction risk and optimal target coverage

Heart dose DIBH-t-IMRT DIBH-t-VMAT Difference p-value
Dmean 2.96 ± 0.61 4.03 ± 0.74 - 1.07 (− 26%) 0.002
D25% 3.84 ± 0.69 4.81 ± 0.81 - 0.97 (−20%) 0.002
D45% 2.68 ± 0.69 3.81 0.63 - 1.13 (−29%) 0.003
LADCA dose
Dmax 12.28 ± 3.49 15.45 ± 5.6 - 3.17 (−20%) 0.003
Dmean 5.80 ± 0.68 7.31 ± 0.97 - 1.51 (−20%) 0.03
D25% 6.58 ± 0.68 8.48 ± 1.18 −1.9 (−22%) 0.01
Left Lung
Dmean 10.42 ± 0.71 9.89 ± 1.03 + 0,53 (+ 5%) 0.006