Fig. 1
Lesion progression as a function of time post-irradiation. The figure shows the lesion size (in mm3) over time (in weeks) for mice that received multiple fractionation regiments as well as single fraction doses between 80 and 100 Gy for T2-Weighted (Panel a) and post-contrast T1-weighted (Panel b) MRI images as well as histological scores at 6 weeks post-irradiation (Panel c). The data is presented as mean ± standard deviation for lesion progression in Panels a and b with mean values present as bars in Panel c. The number of animals in each group (n) ranges from 2 to 25. Notice that the fractionated schemes’ lesion volumes are comparable to those of the three single fraction regiments against the expectations of the SFED seen in Table 1. Also, the post-radiation side effects for single fraction 100 Gy irradiations were severe enough that mice needed to be sacrificed at 2 weeks with data not available past this point. Histological scores for 100 Gy are not in Panel c since post-irradiation side effects required sacrificing these mice early at 2 weeks