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Table 2 Mean ± standard deviation dose metrics for phantom and example patient plans

From: Radiation treatment planning with embedded dose escalation

  Metric Baseline DVH Sub-Structure gEUD (a = − 1) gEUD (a = − 5) gEUD (a = − 15)
Phantoms D0.1 cc (Gy) 27.7 ± 0.8 64.6 ± 10.5 56.5 ± 10.3 48.9 ± 5.7 44.8 ± 5.0 37.4 ± 4.5
gEUD (a = − 1)(Gy) 26.4 ± 0.7 36.1 ± 3.4 33.0 ± 2.0 34.4 ± 4.6 34.4 ± 4.3 31.8 ± 3.6
gEUD (a = − 5) (Gy) 26.3 ± 0.7 32.6 ± 3.1 29.9 ± 1.7 31.7 ± 4.9 32.7 ± 4.1 31.0 ± 3.6
gEUD (a = −15) (Gy) 26.0 ± 0.9 28.6 ± 3.1 26.0 ± 2.1 28.0 ± 5.4 29.9 ± 3.9 29.6 ± 3.3
V150% 0.00 ± 0.00 0.44 ± 0.13 0.32 ± 014 0.41 ± 0.18 0.36 ± 0.25 0.16 ± 0.21
Conformity Index 1.02 ± 0.23 1.15 ± 0.32 1.00 ± 0.18 1.12 ± 0.39 1.18 ± 0.39 1.17 ± 0.36
R50% 4.64 ± 3.27 5.15 ± 2.32 4.83 ± 2.64 4.42 ± 1.83 4.45 ± 1.88 4.21 ± 1.75
Single Fraction MU 795 ± 27 1988 ± 222 1766 ± 259 1612 ± 112 1524 ± 90 1362 ± 146
Mean Segment Size (cm) 4.72 ± 1.55 2.34 ± 0.66 2.61 ± 0.84 2.70 ± 0.69 2.73 ± 0.75 2.81 ± 0.79
Mean Segment Size (normalized) 1.00 ± 016 0.50 ± 0.09 0.55 ± 0.10 0.59 ± 0.12 0.59 ± 0.11 0.61 ± 0.13
Patient - Constrained R50% D0.1 cc (Gy) 99.6 160.2 143.2 97.2 100.2 98.3
gEUD (a = − 1)(Gy) 76.3 81.8 83.3 77.1 76.9 76.4
gEUD (a = − 5) (Gy) 73.5 76.3 76.6 74.0 73.6 73.5
gEUD (a = − 15) (Gy) 57.2 59.4 59.5 56.6 56.1 56.6
V150% 0.0 0.14 0.19 0.0 0.0 0.0
Conformity Index 0.82 0.84 0.83 0.83 0.83 0.84
R50% 3.37 3.37 3.29 3.01 3.15 3.15
Single Fraction MU 834.6 1194.9 1160.2 878.5 862.5 856.5
Mean Segment Size (cm) 4.03 ± 0.01 2.99 ± 0.03 2.95 ± 0.02 3.81 ± 0.04 3.90 ± 0.01 3.96 ± 0.01
Patient – Unconstrained R50% D0.1 cc (Gy) 91.9 267.1 221.8 171.0 119.3 98.2
gEUD (a = −1)(Gy) 79.5 90.2 90.3 98.2 84.9 77.2
gEUD (a = −5) (Gy) 73.2 79.3 79.3 85.1 78.8 74.2
gEUD (a = −15) (Gy) 61.5 61.6 66.1 64.2 55.4 59.5
V150% 0.0 0.29 0.31 0.45 0.11 0.0
Conformity Index 0.86 0.95 0.86 1.07 1.04 0.94
R50% 3.94 5.20 5.04 5.70 4.79 4.02
Single Fraction MU 688.9 1822.8 1682.7 1350.7 957.1 737.2
Mean Segment Size (cm) 4.84 ± 0.03 2.08 ± 0.08 2.02 ± 0.03 2.55 ± 0.08 3.88 ± 0.03 4.65 ± 0.04