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Table 3 GLM summary including odds ratios (OR) and 95% confidence interval (CI) for the prediction of xerostomia

From: Predicting acute radiation induced xerostomia in head and neck Cancer using MR and CT Radiomics of parotid and submandibular glands

 

DVH Model

CT Model

MR Model

Clinical + DVH + CT + MR Model

β

OR

(95% CI)

β

OR

(95% CI)

β

OR

(95% CI)

β

OR

(95% CI)

Intercept

−2.58

–

−9.21

 

−0.31

 

−6.54

 

Age

–

–

–

–

–

–

−0.69

0.50 (0.47–0.54)

Gender

–

–

–

–

–

–

1.09

2.97 (1.93–4.01)

Tumor Volume

–

–

–

–

–

–

0.45

1.56 (1.56–1.58)

cPG D40

1.51

4.57 (4.56–4.58)

–

–

–

–

1.03

2.79 (2.78–2.79)

cSG D60

0.60

1.81 (1.80–1.82)

–

–

–

–

0.63

1.86 (1.86–1.88)

CT cSG wavelet LLL GLSZM Gray Level Non Uniformity Normalized

–

–

1.00

2.73 (−11.3–16.7)

–

–

0.83

2.29 (−14.4–19.0)

CT iPG original GLSZM Low Gray Level Zone Emphasis

–

–

−0.64

0.53 (−9.0–10.1)

–

–

− 0.61

0.55 (−10.4–11.5)

CT iSG wavelet HLL GLCM Inverse Variance

–

–

0.57

1.77 (−17.4–20.9)

–

–

0.36

1.44 (−21.9–24.8)

CT cPG wavelet LHL Total Energy

–

–

0.42

1.53 (1.52–1.54)

–

–

0.31

1.36 (1.35–1.37)

CT iSG wavelet HLL GLRLM Long Run High Gray Level Emphasis

–

–

−0.65

0.52 (0.51–0.53)

–

–

−0.69

0.50 (0.49–0.51)

CT iPG original first order 10 Percentile

–

–

−0.69

0.50 (0.49–0.51)

–

–

−0.38

0.69 (0.68–0.70)

CT cPG wavelet LHL GLRLM Long Run High Gray Level Emphasis

–

–

0.43

1.54 (1.53–1.55)

–

–

0.49

1.63 (1.62–1.64)

MR cPG shape Least Axis Length

–

–

–

–

0.98

2.66 (2.59–2.73)

0.84

2.32 (2.23–2.42)

MR iSG wavelet LHH GLSZM Gray Level Non Uniformity Normalized

–

–

–

–

−0.65

0.52 (−26.2–27.2)

−0.92

0.40 (−33.8–34.6)

MR iSG wavelet LHH GLSZM Small Area High Gray Level Emphasis

–

–

–

–

1.17

3.22 (3.20–3.23)

1.28

3.59 (3.57–3.61)

MR iPG wavelet LHL GLSZM Small Area High Gray Level Emphasis

–

–

–

–

−0.69

0.50 (0.48–0.52)

−0.72

0.49 (0.47–0.51)

MR iSG wavelet LLH GLSZM Size Zone Non Uniformity Normalized

–

–

–

–

−0.36

0.70 (−9.75–11.2)

− 0.43

0.65 (−12.3–13.6)

  1. iPG ipsilateral parotid gland, cPG contralateral parotid gland, iSG ipsilateral submandibular gland, cSG contralateral submandibular gland, GLCM gray level co-occurrence matrix, GLSZM gray level size zone matrix, GLRLM gray level run length matrix; bold indicates significant values (p < .05)