Table 1 Baseline characteristics (n = 214)
Characteristic | n (%) | p | |
|---|---|---|---|
IRF (n = 90) | NIRF (n = 124) | ||
Gender | |||
 Male | 63 (70.0) | 88 (71.0) | 0.878 |
 Female | 27 (30.0) | 36 (29.0) |  |
Age (years) | |||
 < 45 | 14 (15.5) | 13 (10.5) | 0.524 |
 45–59 | 44 (48.9) | 62 (50.0) |  |
 ≥ 60 | 32 (35.6) | 49 (39.5) | |
ECOG | |||
 0 | 66 (73.3) | 96 (77.4) | 0.491 |
 1 | 24 (26.7) | 28 (22.6) |  |
BMI (kg/m2) | |||
 < 18.5 | 3 (3.4) | 4 (3.2) | 0.245 |
 < 25 | 51 (57.3) | 57 (46.0) |  |
 ≥ 25 | 35(39.3) | 63 (50.8) | |
Distance from anal verge (cm) | |||
 ≤ 5 | 83 (92.2) | 116 (93.5) | 0.708 |
 5–6 | 7 (7.8) | 8 (6.5) |  |
c T Stage | |||
 2 | 5 (5.6) | 7 (5.7) | 0.347 |
 3 | 52 (57.8) | 83 (66.9) |  |
 4 | 33(36.6) | 34(27.4) |  |
c N Stage | |||
 0 | 9(10.0) | 3(2.4) | 0.056 |
 1 | 9(10.0) | 15(12.1) |  |
 2 | 72(80.0) | 106(85.5) | |
Diabetes mellitus | |||
 No | 76 (84.4) | 109 (87.9) | 0.466 |
 Yes | 14 (15.6) | 15 (12.1) |  |
Surgical technique | |||
 Open surgery | 67 (74.4) | 73 (58.9) | 0.018 |
 Laparoscopic surgery | 23 (25.6) | 51 (41.1) |  |
Tumour histological type | |||
 Well differentiated adenocarcinoma | 8 (8.9) | 15 (12.1) | 0.059 |
 Moderately differentiated adenocarcinoma | 57 (63.3) | 91 (73.4) |  |
 Poorly differentiated adenocarcinoma, signet ring cell cancer or mucinous adenocarcinoma | 16 (17.8) | 8 (6.4) | |
 Uncertain differentiation type | 9 (10.0) | 10 (8.1) | |
ypCR | |||
 No | 75 (83.3) | 105 (84.7) | 0.791 |
 Yes | 15 (16.7) | 19 (15.3) |  |
ypN+ | |||
 No | 69(76.7) | 100 (80.6) | 0.481 |
 Yes | 21 (23.3) | 24 (19.4) |  |
CRM | |||
 negative | 89 (98.9) | 123 (99.2) | 1 |
 positive | 1 (1.1) | 1 (0.8) |  |
Operation duration (min) | |||
 ≤ 180 | 48(53.3) | 59(47.6) | 0.406 |
 > 180 | 42(46.7) | 65(52.4) |  |
Time interval between NCRT and APR (weeks) | |||
 ≤ 8 | 47 (52.2) | 51 (41.1) | 0.108 |
 > 8 | 43 (47.8) | 73 (58.9) |  |