Factors | n | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
3-year RFS (%) | p-value | HR (95%CI) | p-value | ||
CEA |  |  | < 0.001 |  | < 0.001 |
Increase | 191 | 78.7 |  | 4.60 (2.57–8.23) |  |
Normal | 839 | 95.6 | Â | 1 | Â |
CA-199 | Â | Â | 0.007 | Â | 0.510 |
Increase | 112 | 87.1 |  | 0.77 (0.36–1.67) |  |
Normal | 921 | 93.4 | Â | 1 | Â |
T stage |  |  | < 0.001 |  | 0.29 |
T3–4 | 628 | 88.7 |  | 1.53 (0.69–3.39) |  |
T1–2 | 449 | 94.3 |  | 1 |  |
pN+ |  |  | < 0.001 |  | 0.125 |
Yes | 619 | 88.3 |  | 2.17 (0.81–5.82) |  |
No | 435 | 98.0 | Â | 1 | Â |
N stage |  |  | < 0.001 |  | 0.002 |
pN3 | 232 | 78.5 |  | 2.74 (1.43–5.24) |  |
pN0–2 | 822 | 95.9 |  | 1 |  |
LVI |  |  | < 0.001 |  | 0.003 |
Positive | 206 | 81.5 |  | 2.40 (1.35–4.25) |  |
Negative | 851 | 95.3 | Â | 1 | Â |
Tumor location |  |  | 0.722 | – | – |
Upper one-third | 156 | 93.8 |  | – | – |
Middle one-third | 436 | 93.8 |  | – | – |
Lower one-third | 513 | 91.8 |  | – | – |