Table 2 Univariate and multivariate competing risk analysis of factors associated with risk of loco-regional recurrence

 Male

Reference

–

–

 Female

0.59 (0.32–1.08)

–

–

 <65

Reference

Reference

 ≥ 65

2.02 (1.24–3.27)

1.72 (1.10–2.83)

0.031

 I-III

Reference

–

–

 IV

1.32 (0.93–1.88)

–

–

 Upper one-third

Reference

Reference

 Middle one-third

0.34 (0.16–0.72)

0.42 (0.20–0.90)

0.026

 Lower one-third

0.78 (0.42–1.48)

0.94 (0.49–1.77)

0.84

 Well-moderate differentiated

Reference

–

–

 Poorly differentiated and undifferentiated

1.53 (0.78–2.99)

–

–

 Normal

Reference

Reference

 Increase

2.62 (1.57–4.37)

1.94 (1.09–3.46)

0.024

 Normal

Reference

Reference

 Increase

2.08 (1.12–3.89)

1.04 (0.50–2.18)

0.92

 pT1

Reference

Reference

 pT2

3.72 (1.33–10.44)

2.64 (0.93–7.54)

0.07

 pT3

2.61 (0.91–7.44)

1.48 (0.50–4.35)

0.47

 pT4

5.89 (2.35–14.74)

2.77 (1.01–7.57)

0.047

 No

Reference

Reference

 Yes

2.88 (1.57–5.30)

1.92 (1.09–3.38)

0.024

 Negative

Reference

Reference

 Positive

2.48 (1.48–4.14)

1.84 (1.06–3.20)

0.028

 Negative

Reference

Reference

 Positive

1.64 (0.98–2.77)

1.11 (0.65–1.91)

0.71

 No

Reference

–

–

 Yes

1.23 (0.73–2.08)

–

–

 < 25

Reference

–

–

 ≥ 25

1.24 (0.72–2.13)

–

–