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Table 2 Results for all investigated metrics. While some metrics were investigated on a plan-wise basis (cumulative MU, and the brain receiving 4, 5 and 8 Gy) others were examined on a lesion-wise basis (V10Gy, V12Gy, conformity index, gradient index)

From: Single isocenter stereotactic radiosurgery for patients with multiple brain metastases: dosimetric comparison of VMAT and a dedicated DCAT planning tool

 

MBSRS

DCAT

median (range)

 

Monaco®

VMAT

median (range)

 

P (Wilcoxon SR)

Plan data

N = 20

 

# plans MBSRS superior

 

# plans VMAT superior

 

Cumulative MU

4569 (3543–7790)

17

5840 (4089–10,769)

3

< 0.05

V4Gy (brain) [cm3]

45.6 (18.5–215.9)

19

123.1 (37.5–418.6)

1

< 0.05

V5Gy (brain) [cm3]

33.7 (13.0–120.5)

19

69.1 (26.0–273.6)

1

< 0.05

V8Gy (brain) [cm3]

17.4 (6.3–52.6)

19

26.6 (10.6–86.4)

1

< 0.05

PTV data

N = 59

 

# PTVs MBSRS superior

 

# PTVs VMAT superior

 

V10Gy (healthy brain) [cm3]

3.2 (0.4–19.3)

55

4.9 (1.0–19.9)

4

< 0.05

V12Gy (healthy brain) [cm3]

2.1 (0.1–13.1)

53

3.1 (0.5–13.9)

6

< 0.05

PTV data without PTVs overlapping in half prescribed isodose

N = 53

 

# PTVs MBSRS superior

 

# PTVs VMAT superior

 

Paddick CI

0.75 (0.58–0.89)

30

0.73 (0.38–0.88)

22

< 0.05

GIPTV

5.99 (3.50–15.73)

48

7.17 (3.35–33.00)

5

< 0.05