Table 1 Studies examining hypofractionation protocols
Study | PTV median | D total lung | D oesophagus | D heart | Pneumonitis | Esophagitis |
|---|---|---|---|---|---|---|
Amini et al. 2012 [5] | – | – | – | – | ≥ G2: 14 (11.8%) | ≥ G2: 12 (10.1%) |
Agolli et al. 2015 [6] | 180 cc (73-682 cc) | (α/β = 3Gy) V20 < 25–30%, Mean dose ≤15Gy | (α/β = 3Gy) V42 < 32% | (α/β = 3Gy) V33 < 25% | Acute: G3–4 (6%) Late: G3–2 (3%) °4/5: 0 | Acute: G3–3 (5%) Late: G3–1 (2%) G4/5: 0 |
Westover et al. 2015 [7] | 50Gy: 673 ± 75 cc 55Gy: 646 ± 96 cc 60Gy: 454 ± 68 cc | For all dose steps: V18 < 37% Mean dose < 18Gy 1500 cc 15.5Gy 1000cc 16.3Gy | < 5 cc 51.3Gy Max. dose: 55.3Gy | < 15 cc 39.5Gy Max. dose: 48.9Gy | 50Gy: 5 (33.3%) 55Gy: 4 (19.0%) 60Gy: 4 (21.1%) | 50Gy: 0 55Gy: 1 (4.8%) 60Gy: 1 (5.3%) |
Swanick et al. 2015 [8] | 421.2 cc (46.6–2666.6 cc) | V20 < 30% Mean dose <20Gy | Mean dose <34Gy Max dose: 63.8Gy | Mean Dose <20Gy | G3–1 (1.4%) G4/5: 0 | G3–3 (4.2%) G4–0 G5–1 (1.4%) |
Pollom et al. 2016 [9] | 139 cc (20-746 cc) | V18 < 37% MLD < 18 Gy 1500 cc 15.5Gy 1000cc 16.3Gy | < 5 cc 51.3Gy Max. dose: 55.3Gy | < 15 cc 39.5Gy Max. dose: 48.9Gy | 4 (9.5%) [1 G4 Bronchiopleural fistula] | 5 (11.9%) |