Postoperative elective pelvic nodal irradiation compared to prostate bed irradiation in locally advanced prostate cancer – a retrospective analysis of dose-escalated patients

Table 3 Multivariate survival model for freedom from biochemical failure (FFBF); death unrelated to prostate carcinoma was censored and not counted as an event

Variable	Hazard Ratio	95% CI	P
Elective pelvic radiotherapy (WPRT)	0.493	0.270–0.898	0.021
Detectable tumor and high-dose radiotherapy	0.525	0.259–1.063	0.073
Salvage radiotherapy^c	1.547	0.745–3.215	0.242
Androgen-deprivation therapy (ADT-) usage^a	0.673	0.254–1.786	0.427
PSA values at start of radiotherapy above 0.2 ng/ml	1.631	0.904–2.943	0.104
Higher Gleason score of surgical specimens^b	1.441	1.080–1.922	0.013

^aExcluding ADT-usage as a variable in a sensitivity model did not change results (i.e. WPRT and Gleason remained significant predictors)
^bUsing the Roach score (cut-off of ≥25) instead of Gleason scores did not change the overall model and did not influence WPRT as a significant predictor
^cInclusion of the S-RT-Interval which was not significant in the bPFS univariate model but in the FFBF analysis did not change the overall model and did not influence WPRT as a significant predictor

ISSN: 1748-717X