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Table 1 Baseline characteristics of 120 patients with locally advanced tumors who received fossa-only (n = 77) or elective pelvic nodal irradiation (WPRT; n = 43)

From: Postoperative elective pelvic nodal irradiation compared to prostate bed irradiation in locally advanced prostate cancer – a retrospective analysis of dose-escalated patients

Baseline Characteristics Fossa-only (n = 77) WPRT (n = 43) Difference
Age at radiation therapy in years
 Mean 66.9 66.9 p = 0.98
 Standard deviation 7.5 6.5  
Initial PSA value in ng/ml
 Mean 18.1 18.6 p = 0.927
 Standard deviation 26.8 18.0  
Gleason score (surgical specimens, No., percentage)
 Gleason 6 2 (2.6%) 0  
 Gleason 7a 15 (19.5%) 9 (20.9%)  
 Gleason 7b 30 (39.0%) 10 (23.3%) p = 0.087§
 Gleason 8 7 (9.1%) 4 (9.3%)  
 Gleason 9 22 (28.6%) 19 (44.2%)  
 Gleason 10 1 (1.3%) 1 (2.3%)  
Surgical margin (No., percentage)
 R0 29 (37.7%) 16 (37.2%) p = 1.0
 R1 48 (62.3%) 27 (62.8%)  
 R2  
Dose level (Gy, prescribed dose, EQD-2 to PTV-2)
 Lower-dose (71.43 Gy) 29 (37.7%) 13 (30.2%) p = 0.433
 High-dose (79.29 Gy) 48 (62.3%) 30 (69.8%)  
Time from surgery to radiation therapy (S-RT-Interval in months)
 Mean 13.3 6.1 p = 0.003#
 Median 5.1 3.6  
 Standard deviation 18.7 6.2  
Salvage or postoperative (adjuvant or R1) treatment indication (No., percentage)
 Salvage 41 (53.2%) 17 (39.5%) p = 0.184
 Postoperative 36 (46.8%) 26 (60.5%)  
Roach scores
 Mean 28.9 32.8 p = 0.27
 Standard deviation 20.8 15.0  
Concurrent androgen deprivation therapy (ADT)
 Yes 7 (9.1%) 6 (14%) p = 0.541
 No 70 (90.9%) 37 (86%)  
Pathologically identified number of lymph nodes (all N0)
 Mean 11.0 5.9 p < 0.001
 Standard deviation 6.5 3.9  
  ≥ 10 nodes identified 42 (54.5%) 2 (4.7%)  
  < 10 nodes identified 35 (45.5%) 41 (95.3%)  
Post-surgery PSA at start of radiotherapy (if available) in ng/ml
 Mean 0.73 0.71 p = 0.958
 Standard deviation 1.62 1.66  
Laparoscopic or retropubic surgery
 Laparoscopic 31 (40.3%) 23 (53.5%) p = 0.184
 Retropubic 46 (59.7%) 20 (46.5%)  
  1. §Fisher’s exact test, 2-sided for Gleason scores dichotomized at 7 (6–7 vs. 8–10); one-sided testing results in p = 0.056 for an increased Gleason score in the WPRT group
  2. #The baseline imbalance was significant using the independent samples T-test; imbalance was mainly due to outliers (non-parametric testing did not show a significant difference: p = 0.07 for Mann-Whitney U-Test
  3. WPRT was not routinely recommended in patients with ≥10 lymph nodes resected and only performed in two cases after careful discussion with patients. If no lymph node dissection was performed, the number was scored as zero