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Fig. 4 | Radiation Oncology

Fig. 4

From: Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy

Fig. 4

Validation of the FRoG dose engine for helium ion beam therapy dose calculation with a glioma patient case. DRBE applying (a) DDM and (b) LETd is displayed, along with dose difference between DRBE applying DDM and (c) LEM and (d) MKM. DVH and DRBEVH for the three biological models are depicted for the PTV (right panel) for FRoG versus FLUKA. The yellow arrow directs attention to the LETd gradient at the distal edge of the tumor, which could lead to larger uncertainty in RBE prediction for both the tumor and neighboring heathy issues beyond the target

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